Method for treating disorders of the vascular and pulmonary systems

• US 4,636,384 A
• Filed: 10/27/1983
• Issued: 01/13/1987
• Est. Priority Date: 06/03/1982
• Status: Expired

• Current Assignee: Stolle Research & Development Corporation
• Original Assignee: Stolle Research & Development Corporation
• Inventors: Stolle, Ralph J., Beck, Lee R.
• Primary Examiner(s): Hazel, Blondel
• Application Number:
  US06/546,162
• Time in Patent Office: 1,174 Days
• Field of Search: 424/85-92
• US Class Current: 424/157.1
• CPC Class Codes: A23C 9/20 Dietetic milk products not covered by groups A23C9/12 - A23C9/18
• CPC Class Codes: A23L 33/10 using additives addition of substantially indigestible substances A23L33/21
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/324 having an effect on the immune system
• CPC Class Codes: A23V 2250/5424 Dairy protein
• CPC Class Codes: A24B 15/30 by organic substances A24B15/281 takes precedence
• CPC Class Codes: A61K 35/20 Milk; Whey; Colostrum
• CPC Class Codes: A61K 39/39508 from milk, i.e. lactoglobulins
• CPC Class Codes: C07K 2317/11 isolated from eggs

Abstract

A method for treating vascular disorders or pulmonary disorders associated with smoking in an animal which comprises: adminstering to the animal milk collected from a bovid being maintained in a hyperimmune state, in an amount and for a time sufficient to produce anti arteriosclerotic or antiaging vascular effects or sparing effects on lung tissue.

Claims

1. A method of lowering lipid blood stream levels in an animal which comprises:

administering to said animal milk collected from a bovid being maintained in a hyperimmune state against a mixture of antigens comprising Staphylococcus aureus;

Staphylococcus epidermidis;

Streptococcus pyogenes, A. Type 1;

Streptococcus pyogenes, A. Type 3;

Streptococcus pyogenes, A. Type 5;

Streptococcus pyogenes, A. Type 8;

Streptococcus pyogenes, A. Type 12;

Streptococcus pyogenes, A. Type 14;

Streptococcus pyogenes, A. Type 18;

Streptococcus pyogenes, A. Type 22;

Aerobacter aerogenes;

Escherichia coli;

Salmonella enteritidis;

Pseudomonas aeruginosa;

Klebsiella pneumoniae;

Salmonella typhimurium;

Haemophilus influenzae;

Streptococcus viridans;

Proteus vulgaris;

Shigella dysenteriae;

Streptococcus, Group B;

Diplococcus pneumoniae;

Streptococcus mutans; and

Corynebacterium Acne, Types 1 and 2, in an amount and for a time sufficient to produce said lowering effect.

2. The method of claim 1 wherein said milk is in powdery form.

3. The method of claim 1 wherein said milk is in fluid form.

4. The method of claim 1 wherein said milk is in concentrated form.

5. The method of claim 1 wherein said milk is incorporated into a food product.

6. The method of claim 4 wherein said product is yogurt.

7. The method of claim 1 wherein said bovid is a cow.

8. The method of claim 1 wherein said bovid is maintained in said hyperimmune state by administering to said bovid booster injections of a mixture of antigens comprising Staphylococcus aureus;

Staphylococcus epidermus;

Streptococcus pyogenes, A. Type 1;

Streptococcus pyogenes, A. Type 3;

Streptococcus pyogenes, A. Type 5;

Streptococcus pyogens, A. Type 8;

Streptococcus pyrogenes, A. Type 12;

Streptococcus pyogenes, A. Type 14;

Streptococcus pyogenes, A. Type 18;

Streptococcus pyogenes, A. Type 22;

Aerobacter aerogenes;

Escherichia coli;

Salmonella enteritidis;

Pseudomonas aeruginosa;

Klebsiella pneumoniae;

Salmonella typhimurium;

Haemophilus influenzae;

Streptococcus viridans;

Proteus vulgaris;

Shigella dysenteriae;

Streptococcus, Group B;

Diplococcus pneumoniae;

Streptococcus mutans; and

Corynebacterium Acne, Types 1 and 2.

9. The method of claim 8 wherein said antigen or mixture of antigens booster is injected in a dose of 10⁶ cells to 10²⁰ cells.

10. The method of claim 4 wherein said milk is prepared by a process which comprises:

sensitizing a bovid with said mixture of antigens;

administering boosters of said mixture of antigens of a dosage sufficient to induce and maintain a hyperimmune state in said bovid, and thereafter collecting said milk from said bovid.

11. The method of claim 10 wherein said process further comprises:

pasteurizing said collected milk; and

removing the fat from said milk.

12. The method of claim 1 wherein said milk is administered daily.

13. The method of claim 1, wherein said lipids are selected from the group consisting of triglycerides, cholesterol, low density lipids and mixtures thereof.