×

Stabilized, lipid membrane-based device and method of analysis

  • US 4,637,861 A
  • Filed: 12/16/1985
  • Issued: 01/20/1987
  • Est. Priority Date: 12/16/1985
  • Status: Expired due to Fees
First Claim
Patent Images

1. A stabilized, lipid membrane-based device comprising a perturbable lipid membrane and a membrane-stabilizing support, said lipid membrane including a complexing agent for selectively interacting with a specified chemical species to perturb said lipid membrane;

  • wherein each membrane-forming lipid includes a polar head group, a first long chain through which the lipid is anchored to a binding site on said support, and a fluidity-providing, second long chain, which is unattached to said support; and

    wherein the binding sites on said support are spaced appropriately apart from one another to provide a lipid molecular packing density that permits axial rotation of each membrane-forming lipid about its anchored, long chain, and are yet sufficiently close to one another so that said lipid molecular packing density provides a relatively high ion impermeability to said lipid membrane when unperturbed;

    said lipid membrane having an increased ion permeability when perturbed.

View all claims
  • 0 Assignments
Timeline View
Assignment View
    ×
    ×