Polyactic-polyglycolic acid copolymer combined with decalcified freeze-dried bone for use as a bone repair material
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1. A method for promoting the healing of osseous tissue which comprises implanting at the site of the broken osseous tissue a therapeutically-effective amount of a composition comprising decalcified freeze-dried bone incorporated into a biodegradable polymeric matrix comprised of a copolymer of poly(L)(-)lactide co-glycolide.
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Abstract
A novel bone repair material consisting essential of decalcified freeze-dd bone and biodegradable, biocompatible copolymer has been developed for improving and accelerating the healing of osseous tissue. The bone repair material was prepared by combining decalcified bone with a copolymer consisting essentially of a 50:50 poly(L)(-)lactide co-glycolide.
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19 Claims
- 1. A method for promoting the healing of osseous tissue which comprises implanting at the site of the broken osseous tissue a therapeutically-effective amount of a composition comprising decalcified freeze-dried bone incorporated into a biodegradable polymeric matrix comprised of a copolymer of poly(L)(-)lactide co-glycolide.
- 11. A pharmaceutical composition useful in promoting the healing of broken osseous tissue comprising decalcified freeze-dried bone incorporated into a biodegradable polymeric matrix comprised of a copolymer of poly(L)(-)lactide co-glycolide.
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