Polymers containing pendant acid functionalities and labile backbone bonds

• US 4,639,366 A
• Filed: 06/06/1984
• Issued: 01/27/1987
• Est. Priority Date: 06/06/1984
• Status: Expired due to Fees

• Current Assignee: Merck & Co., Inc.
• Original Assignee: Merck & Co., Inc.
• Inventors: Heller, Jorge
• Primary Examiner(s): Kight, John
• Assistant Examiner(s): NOT, DEFINED
• Application Number:
  US06/618,002
• Time in Patent Office: 965 Days
• Field of Search: 424/22, 424/78, 424/19, 424/20
• US Class Current: 424/484
• CPC Class Codes: A61K 9/204 Polyesters, e.g. poly(lactide-co-glycolide)
• CPC Class Codes: C08G 65/34 from hydroxy compounds or their metallic derivatives C08G65/26 takes precedence
• CPC Class Codes: C08G 85/00 General processes for preparing compounds provided for in this subclass

Abstract

The instant invention is directed to a polymer with at least one labile backbone bond per repeat unit and at least one pendant acid functionality per thousand repeat units.

The instant invention is also directed to a controlled release device which comprises:

(A) a polymer with at least one labile backbone bond per repeat unit and at least one pendant acid functionality per thousand repeat units; and

(B) a beneficial substance incorporated within or surrounded by the matrix of said polymer.

Claims

1. A polymer with at least one labile backbone bond per repeat unit and at least one pendant acid functionality per thousand repeat units.

2. The polymer of claim 1, wherein the backbone of the polymer is selected from the group consisting of polyorthoesters, polyacetals, polyketals, polyesters and polyphosphazenes.

3. The polymer of claim 1, wherein the pendant acid functionality is selected from the group consisting of carboxylic, phosphoric, sulfonic and sulfenic.

4. The polymer of claim 1, prepared from a diol containing a pendant acid functionality selected from the group consisting of 9,10-dihydroxystearic acid;

3,6-dihydroxynaphthalene-2,7-disulfonic acid;

2,4-dihydroxybenzoic acid;

3,4-dihydroxycinnamic acid;

3,4-dihydrocinnamic acid;

6,7-dihydroxy-2-naphtahalene sulfonic acid;

2,5-dihydroxyphenylacetic acid;

2,4-dihydroxypyrimidine-5-carboxylic acid;

4,8-dihydroxyquinoline-2-carboxylic acid; and

mixtures thereof; and

at least one additional monomer selected from the group consisting of esters, acetals and mixtures thereof.