Optimized nerve fiber stimulation
First Claim
1. A method for optimizing electrical stimulation of nerve fibers having predetermined refractory periods and enhanced excitability conditions that occur during known periods following the occurrence of an action potential, said method comprising:
- generating a first pulse of positive polarity and applying said first pulse to nerve fibers to be electrically stimulated to thereby set said fibers;
generating a second pulse of negative polarity and applying said second pulse to said nerve fibers to be electrically stimulated to cause excitation thereof, with said second pulse being generated at a time subsequent to said first pulse that is substantially equal to that of the refractory period for said nerve fibers then to be stimulated; and
repeatedly generating said first and second pulses with each occurrence of said first and second pulses being timewise spaced from each adjacent first and second pulses a distance based upon the timewise occurrence of said enhanced excitability condition of said preselected nerve fibers to be stimulated to thereby optimize stimulation of said nerve fibers and substantially increase the activity thereof.
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Accused Products
Abstract
Optimization of nerve fiber stimulation to substantially increase the activity of the then selected nerve fibers is disclosed, with optimization being achieved through utilization of electrical pulses that are caused to occur in a predetermined pattern with respect to polarity, spacing, frequency and duration so as to interact with the electro-neurophysiological characteristics of the particular nerve fibers then to be electrically stimulated. Bi-phased pulse pairs are repeatedly generated and applied to the nerve fibers to be stimulated with the first pulse of each pulse pair being a positive polarity pulse causing the nerve to be set into the refractory period, while the second pulse of each pulse pair is a negative polarity pulse that is made to occur substantially at the end of the refractory period for the particular nerve fibers then being stimulated to thereby excite those nerve fibers, and the pulse pairs are repeated at a rate based upon the timewise occurrence of the enhanced excitability condition of the nerve fibers then being stimulated. Electrode polarity is absolute, meaning that nerve activity is stimulated almost entirely adjacent to the electrode which has the polarity relationship as above stated. Frequency of occurrence of the pulse pairs and duration of the pulses are preselected to provide a cumulative optimizing effect. Additional normal pulses occurring during the period following occurrence of the first pulse of the pair and before the occurrence of the second pulse of the pair do not normally adversely affect performance, and interleaved pulses can therefore be utilized to simultaneously stimulate a plurality of different types of nerve fibers without adversely affecting optimum stimulation of at least one selected type of the plurality of types of nerve fibers then being stimulated.
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Citations
25 Claims
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1. A method for optimizing electrical stimulation of nerve fibers having predetermined refractory periods and enhanced excitability conditions that occur during known periods following the occurrence of an action potential, said method comprising:
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generating a first pulse of positive polarity and applying said first pulse to nerve fibers to be electrically stimulated to thereby set said fibers; generating a second pulse of negative polarity and applying said second pulse to said nerve fibers to be electrically stimulated to cause excitation thereof, with said second pulse being generated at a time subsequent to said first pulse that is substantially equal to that of the refractory period for said nerve fibers then to be stimulated; and repeatedly generating said first and second pulses with each occurrence of said first and second pulses being timewise spaced from each adjacent first and second pulses a distance based upon the timewise occurrence of said enhanced excitability condition of said preselected nerve fibers to be stimulated to thereby optimize stimulation of said nerve fibers and substantially increase the activity thereof. - View Dependent Claims (2, 3, 4, 7, 8)
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5. A device for providing optimized electrical stimulation to preselected nerve fibers having known refractory periods and enhanced excitability conditions that occur during known periods following the occurrence of an action potential, said device comprising:
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generating means for generating a series of pulse pairs with each said pair having first and second pulses of positive and negative polarity, respectively, and with said first pulse occurring timewise before said second pulse, said pulses of each said pulse pair being spaced from one another a distance, in time, substantially equal to that of the known refractory period of said preselected nerve fibers to be stimulated, and each pulse pair of said series of pulse pairs occurring so as to be timewise spaced from each adjacent pulse pair a distance based upon the timewise occurrence of said enhanced excitability condition of said preselected nerve fibers to be stimulated; and application means connected with said generating means and adapted to apply said series of pulse pairs to said preselected nerve fibers so that said first pulse of each said pulse pair sets said preselected nerve fibers, and so that said second pulse of each said pulse pair occurs substantially at the end of said refractory period to excite said preselected nerve fibers, whereby said applied pulse pairs optimize stimulation of said preselected nerve fibers and thereby substantially increase the activity thereof. - View Dependent Claims (6, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A device for providing electrical stimulation to a plurality of nerve fibers having different known refractory periods and enhanced excitability conditions that occur following the occurrence of an action potential, said device comprising:
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generating means for generating a series of pulse groups each having first, second and third pulses with said first pulse of each said pulse group being a positive polarity pulse and said second and third pulses of each said pulse group being negative polarity pulses, said first and second pulses of each said pulse group being spaced, in time, from one another a distance substantially equal to the known refractory period of first preselected nerve fibers, said first and third pulses of each said pulse group being spaced, in time, from one another a distance substantially equal to that of the known refractory period of second preselected nerve fibers, said second and third pulses of each said pulse group being also spaced from one another, and each pulse group occurring so as to be timewise spaced from each adjacent pulse group a distance based upon the occurrence of said enhanced excitability condition of one of said first and second preselected nerve fibers to be stimulated; and application means connected with said generating means to receive said pulses therefrom and adapted to apply said pulses to said nerve fibers so that said first pulse of each said pulse group sets said first and second preselected nerve fibers, and so that said second and third pulses of each said pulse group occur substantially at the end of said refractory period for said first and second preselected nerve fibers, respectively, to excite said first and second preselected nerve fibers, whereby said applied pulse groups stimulate both said first and second nerve fibers to increase the activity of both said first and second nerve fibers with at least one of said first and second nerve fibers being optimally stimulated.
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Specification