Means for providing instant agent from agent dispensing system

• US 4,643,731 A
• Filed: 08/16/1985
• Issued: 02/17/1987
• Est. Priority Date: 08/16/1985
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Eckenhoff, James B.
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): Smith, Jr., Jerome R.
• Application Number:
  US06/766,454
• Time in Patent Office: 550 Days
• Field of Search: 604/890-892, 604/893-897, 424/15-21, 424/117, 427/3
• US Class Current: 604/892.1
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

A dispensing system is disclosed for delivering a beneficial agent formulation instantly and continuously over time to an environment of use. The dispensing system comprises an outer housing surrounding at least a part of a dispensing device. The dispensing device comprises a wall surrounding a compartment with a passageway in the wall connecting the compartment with the interior of the dispensing device. A beneficial agent formulation is present in the housing for instant delivery and a beneficial agent formulation is present in the compartment for continuous delivery.

Claims

1. A dispensing system for delivering a beneficial agent formulation to an environment of use, the dispensing system comprising:

(a) a first means for delivering continously a beneficial agent formulation to an environment of use, said first means comprising;

(1) a first wall that maintains its physical and chemical integrity in the environment of use and comprising in at least a part a polymeric composition permeable to the passage of fluid present in the environment of use, which wall surrounds and defines;

(2) a compartment;

(3) a beneficial agent in the compartment; and

,

(4) exit means in the wall for continuously delivering the beneficial agent formulation from the first means to the environment of use over a prolonged period of time; and

,

(b) a second means for making a beneficial agent formulation instantly available to the environment of use, said second means comprising;

(1) a second wall comprising a composition that loses its physical and chemical integrity in the environment of use for instantly making a beneficial agent formulation available to the environment of use, which wall telescopically caps, surrounds and encloses a portion of the first means and forms;

(2) a lumen between the first means and the second means formed by the telescopically capped arrangement; and

,

(3) a beneficial agent formulation in the lumen available by the telescopically capped second wall losing its physical and chemical integrity in the environment of use for instant delivery of said beneficial agent by the second means to the environment of use.

2. The dispensing system for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the beneficial agent formulation in the compartment exhibitis an osmotic pressure gradient across the first wall against an external fluid, imbibes fluid through the wall and is osmotically delivered through the exit means for releasing the beneficial agent to the environment of use.

3. The dispensing system for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the compartment comprises an expandable member that absorbs fluid imbibed through the first wall into the compartment, expands and urges beneficial agent formulation through the exit means to the environment of use.

4. The dispensing system for delivering the beneficial agent formulation to the environment of use according to claim 1, where in the beneficial agent formulation in the compartment comprises a thermo-sensitive carrier that is solid at room temperature and dispensable through the exit means at the temperature of the environment of use.

5. The dispensing system for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the compartment comprises a dense member having a specific gravity greater than one for keeping the dispensing system in the environment of use.

6. A dispensing system for delivering a beneficial agent formulation to an environment of use, the dispensing system comprising:

(a) a first means for delivering continuously a beneficial agent formulation to an environment of use, said first means comprising;

(1) a first wall comprising a composition that maintains its physical and chemical integrity in the environment of use and comprising at least in part a polymeric composition permeable to the passage of fluid present in the environment of use, which wall surrounds and defines;

(2) a compartment;

(3) a beneficial agent in the compartment; and

,

(4) means in the wall for continuously delivering the beneficial agent formulation from the first means to the environment of use over a prolonged period of time; and

,

(b) a second means for making a beneficial agent formulation instantly available to the environment of use, said second means comprising;

(1) a second wall comprising a composition that loses its physical and chemical integrity for instantly making a beneficial agent formulation available to the environment of use, which wall surrounds and encloses all of the first means and forms;

(2) a lumem between the first means and the second means; and

,

(3) a beneficial agent formulation in the lumen available by the second wall losing its physical and chemical integrity in the environment of use for instant delivery of the beneficial agent to the environment of use.

7. The dispensing system for delivering the beneficial agent formulation to the environment of use according to claim 6, wherein the beneficial agent formulation in the compartment exhibits and osmotic pressure gradient across the first wall against an external fluid, imbibes fluid through the wall and is osmotically delivered through the means for releasing the beneficial agent to the environment of use.

8. The dispensing system for delivering the beneficial agent formulation to the environment of use according to claim 6, wherein the compartment comprises an expandable member that absorbs fluid imbibed through the wall into the compartment, expands and urges beneficial agent formulation through the exit means to the environment of use.

9. The dispensing system for delivering the beneficial agent formulation to the environment of use according to claim 6, wherein the beneficial agent formulation comprises a thermo-sensitive carrier that is solid at room temperature and dispensable through the exit means at the temperature of the environment of use.

10. The dispensing system for delivering the beneficial agent formulation to the environment of use according to claim 6, wherein the compartment comprises a dense member having a specific gravity greater than one for keeping the dispensing system in the environment of use.

11. The dispensing system for delivering the beneficial agent formulation to the environment of use according to claim 6, wherein the second wall comprises two parts for telescopically surrounding the first means.

12. The dispensing systen for delivering the beneficial agent formulation to the environment of use according to claim 6, wherein the second wall comprises a single piece.