Chiral borane reagents

• US 4,644,075 A
• Filed: 12/09/1985
• Issued: 02/17/1987
• Est. Priority Date: 12/09/1985
• Status: Expired due to Fees

• Current Assignee: Massachusetts Institute of Technology
• Original Assignee: Massachusetts Institute of Technology
• Inventors: Masamune, Satoru
• Primary Examiner(s): Shaver, Paul F.
• Application Number:
  US06/807,096
• Time in Patent Office: 435 Days
• Field of Search: 556/403, 568/1, 568/3
• US Class Current: 556/403
• CPC Class Codes: C07F 5/025 Boronic and borinic acid compounds
• CPC Class Codes: C07F 5/027 Organoboranes and organoborohydrides
• CPC Class Codes: C07F 7/0803 Compounds with Si-C or Si-Si linkages

Abstract

Chiral borane reagents and their organosilicon derivatives are disclosed.

Claims

1. A compound of the formula:

wherein R is a primary or secondary alkyl or trimethylsilyl group.

2. The compound of claim 1 having the structure of 1a wherein R is methyl.

3. The compound of claim 1 having the structure of 1b wherein R is methyl.

4. The compound of claim 1 having the structure of 1a wherein R is ethyl.

5. The compound of claim 1 having the structure of 1b wherein R is ethyl.

6. The compound of claim 1 having the structure of 1a wherein R is isopropyl.

7. The compound of claim 1 having the structure of 1b wherein R is isopropyl.

8. The compound of claim 1 having the structure of 1a wherein R is trimethylsilyl.

9. The compound of claim 1 having the structure of 1b wherein R is trimethylsilyl.

10. The compound of claim 1 having the structure of 1c wherein R is methyl.

11. The compound of claim 1 having the structure of 1d wherein R is methyl.

12. The compound of claim 1 having the structure of 1d wherein R is ethyl. PG,33

13. The compound of claim 1 having the structure of 1d wherein R is ethyl.

14. The compound of claim 1 having the structure of 1c wherein R is isopropyl.

15. The compound of claim 1 having the structure of 1d wherein R is isopropyl.

16. The compound of claim 1 having the structure of 1c wherein R is trimethylsilyl.

17. The compound of claim 1 having the structure of 1d wherein R is trimethylsilyl.