Infiltration detection apparatus

• US 4,647,281 A
• Filed: 02/20/1985
• Issued: 03/03/1987
• Est. Priority Date: 02/20/1985
• Status: Expired due to Term

• Current Assignee: Microwave Medical Systems Incorporated (General Electric Company)
• Original Assignee: M/A Com, Inc. (MACOM Technology Solutions Holdings, Inc.)
• Inventors: Carr, Kenneth L.
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): NOT, DEFINED
• Application Number:
  US06/703,326
• Time in Patent Office: 741 Days
• Field of Search: 604/31, 604/50, 604/65, 604/66, 604/67, 604/245, 128/736, 128/653, 128/742, 343/718
• US Class Current: 604/503
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/0507 using microwaves or terahertz waves
• CPC Class Codes: A61M 5/16836 by sensing tissue properties at the infusion site, e.g. for detecting infiltration detecting tissue temperature for diagnostic purposes A61M39/0247

Abstract

An apparatus used in association with a needle for infusing a liquid. This apparatus is for detecting the infiltration of the liquid through the vascular wall into the perivascular tissues. The apparatus includes a non-invasive conformal microwave antenna means adapted to be positioned over the area where liquid infusion occurs. A microwave radiometer connects from the antenna means for detecting sub-cutaneous temperature at the site thereof. A reference antenna means is also employed so that a proper temperature differential can be established. In an alternate version of the invention, switching means is provided so that upon detecting an alarm condition, the liquid can be immediately terminated and a neutralizing agent can be introduced to the needle.

Claims

1. A method for rapidly detecting the infiltration of a liquid from a source thereof through the vasuclar wall into the perivascular tissue, comprising the steps of, providing a non-invasive conformal microwave antenna, disposing said antenna on the skin at the area where liquid infusion into a blood vessel is to occur, establishing a reference, providing a microwave radiometer coupled from said microwave antenna, detecting the sub-cutaneous temperature at the site of the antenna with the use of said microwave radiometer, and rapidly signaling as alarm condition upon detecting a predetermined temperature differential between temperature sensed by said microwave radiometer and said reference.

2. A method as set forth in claim 1 further including providing a second non-invasive conformal microwave antenna used as a reference antenna to establish said reference and spacedly disposing said second antenna from said first antenna that is positioned over the area where liquid infusion occurs.

3. A method as set forth in claim 2 including providing a second microwave radiometer connected from the second antenna for also detecting sub-cutaneous temperature at the site of the second antenna.

4. A method as set forth in claim 3 comprising providing a comparator coupled from the outputs of the respective microwave radiometers, said comparator providing an output trigger signal when the temperature differential reaches a predetermined value.

5. A method as set forth in claim 4 including providing a source of neutralizing agent and switching between said source of neutralizing agent and said liquid source so that in one instance there is a coupling of said liquid to the liquid infusion means and having another state responsive to the triggering of said comparator means for interrupting primary liquid flow to the liquid infusion means and instead coupling the neutralizing agent to the luquid-infusing means.

6. A method as set forth in claim 1 wherein said apparatus has a fast response time providing at least 1°

C. of temperature differential for one milliliter of infusion.

7. A method as set forth in claim 1 including providing on said non-invasive conformal microwave antenna oppositely disposed adhesive strips and a central antenna section.

8. A method as set forth in claim 7 wherein said central antenna section comprises a flexible plastic layer having a metallic antenna configuration on at least one side thereof.

9. A method as set forth in claim 8 wherein said antenna configuration is of bow-tie shape.

10. A method as set forth in claim 9 including providing a second conductive layer on the opposite side of said plastic sheet.

11. A method as set forth in claim 7 wherein said central antenna section comprises a plastic bag that is liquid filled.

12. A method as set forth in claim 7 wherein said central antenna section comprises a plastic bag that is powder filled.

13. A method as set forth in claim 7 wherein said central antenna section comprises a plastic bag that is liquid filled and that has an antenna element disposed on the inner surface thereof.

14. A method as set forth in claim 7 wherein said central antenna section comprises a plastic bag that is filled with microwave powder and which has an antenna element disposed on the inside surface thereof.

15. A method of rapidly detecting liquid-infusion infiltration into the skin of a patient from a liquid source of infusion liquid in which there is provided a liquid-infusion delivery conduit placed into a blood vessel of the patient for delivery of the infusion liquid into the blood vessel of the patient, said method comprising the steps of, providing a non-invasive conformal and substantially planar microwave antenna, disposing said antenna on the skin at the area where liquid infusion into the blood vessel is to occur, continuously monitoring sub-cutaneous temperature at the site of the antenna as the liquid is infused with the use of a microwave radiometer, and signaling an alarm condition upon detecting a predetermined temperature deviation from normal skin temperature.

16. A method as set forth in claim 15 including providing a second antenna spaced from the first antenna for establishing a reference temperature so as to determine said predetermined temperature deviation.

17. A method as set forth in claim 16 including spacing said second antenna from said first antenna by a distance on the order of one-half wavelength of the operating frequency of the microwave radiometer.

18. A method as set forth in claim 16 including providing a first radiometer associated with the first antenna and a second radiometer associated with the second antenna.

19. A method as set forth in claim 18 including providing a comparison between the output temperatures sensed by the first and second radiometers to determine temperature deviation.

20. A method as set forth in claim 16 including a single radiometer that is switched to read in sequence both antennas.

21. A method as set forth in claim 15 including providing a source of neutralizing agent and providing a switch to switch between neutralizing agent and liquid-infusion source.

22. A method as set forth in claim 21 wherein the liquid is coupled to the blood vessel until a predetermined temperature deviation is detected in which case the coupling of the neutralizing agent is to the blood vessel.

23. A method as set forth in claim 15 including establishing a reference signal and comparing the temperature sensed by the microwave radiometer with said reference signal.