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Implantable biological tissue and process for preparation thereof

  • US 4,647,283 A
  • Filed: 11/13/1984
  • Issued: 03/03/1987
  • Est. Priority Date: 03/23/1982
  • Status: Expired due to Term
First Claim
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1. A process for treating biological tissue prior to implantation which comprises the steps of:

  • a. fixing said tissue under tissue fixing conditions;

    b. contacting said fixed tissue with a solution effective in reducing calcification of said tissue after implantation;

    said calcification reducing solution comprising an amount of a calcium-binding competing divalent cation effective in reducing calcification and having a level of phosphate decreased to an amount effective in reducing calcification of tissue after implantation; and

    c. maintaining the tissue in contact with a solution having said reduced level of phosphate to a time just prior to implantation.

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