Apparatus for the measurement of fluid flow

• US 4,650,458 A
• Filed: 06/07/1985
• Issued: 03/17/1987
• Est. Priority Date: 06/18/1984
• Status: Expired due to Fees

• Current Assignee: Gambro Lundia AB (Baxter International Inc.)
• Original Assignee: Gambro Lundia AB (Baxter International Inc.)
• Inventors: Simonsson, Tord B., Ohlsson, Lars I., Dahlberg, Bengt A. G., Jeppsson, Jan-Bertil
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): NOT, DEFINED
• Application Number:
  US06/742,586
• Time in Patent Office: 648 Days
• Field of Search: 604/30, 604/5, 604/6, 604/4, 604/246, 604/247, 604/45, 604/126, 604/122, 604/123, 55/158, 210/927, 210/136, 210/472, 210/436, 210/433.2, 210/321.2, 210/321.3, 128/D3
• US Class Current: 604/6.06
• CPC Class Codes: A61M 1/34 Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
• CPC Class Codes: A61M 1/3403 Regulation parameters
• CPC Class Codes: A61M 1/3441 Substitution rate control as a function of the ultrafiltration rate
• CPC Class Codes: A61M 1/3468 using treated filtrate as substitution fluid
• CPC Class Codes: A61M 1/3627 Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
• CPC Class Codes: A61M 2205/3331 Pressure; Flow

Abstract

Apparatus is disclosed for the measurement and replacement of physiological fluids including a meter for measuring the amount of a physiological fluid flowing through the meter, a first conduit for continuously delivering the physiological fluid to the meter, a second conduit for replacing the measured amount of physiological fluid with a corresponding amount of a replacement fluid, and a pressure equalizer associated with the first conduit for equalizing the pressure in the physiological fluid flowing through the first conduit whereby the flow of the physiological fluid through the meter is substantially unaffected by pressure variations in the physiological fluid itself.

Claims

1. Apparatus for the measurement of a filtrate separated from a supply of blood and replacement of said filtrate with a replacement fluid as a substitute for said filtrate in said blood comprising measuring means for measuring the amount of said filtrate flowing therethrough, first conduit means for continuously delivering said filtrate to said measuring means, second conduit means for supplying an amount of a replacement fluid as a substitute for said measured amount of said filtrate, pump means associated with said first conduit means for drawing said filtrate through said first conduit means into said measuring means, and pressure equalizing means associated with said first conduit means and located at a point in said first conduit means between said pump means and said measuring means for equalizing the pressure in said filtrate flowing through said first conduit means, whereby the flow of said filtrate through said measuring means is substantially unaffected by pressure variations in said filtrate.

2. The apparatus of claim 1, including filter means for contacting with said supply of blood so as to produce said filtrate therefrom.

3. The apparatus of claim 1, wherein said pressure equalizing means is located at a point in said first conduit means substantially adjacent to said measuring means.

4. The apparatus of claim 1, wherein said pressure equalizing means includes bubble collection means for collecting any gas bubbles contained within said filtrate so as to prevent said gas bubbles from being delivered to said measuring means.

5. The apparatus of claim 1, wherein said pump means comprises a peristaltic pump, whereby said pump means can contact the outer surface of said first conduit means for drawing said filtrate therethrough.

6. The apparatus of claim 1, wherein said measuring means comprises first measuring means, and including second measuring means for measuring the amount of said replacement fluid flowing into said second conduit means.

7. The apparatus of claim 6, including comparison means for comparing the amounts of said filtrate and said replacement fluid measured by said first and second measuring means, respectively.

8. The apparatus of claim 1, wherein said pressure equalizing means comprises first pressure equalizing means, and including second pressure equalizing means, said second pressure equalizing means being associatd with said second conduit means for equalizing the pressure in said replacement fluid flowing through said second conduit means.

9. The apparatus of claim 8, wherein at least one of said first and second pressure equalizing means includes a housing and fluid level control means for maintaining the level of said fluid within said housing at a predetermined level therein.

10. The apparatus of claim 8, wherein at least one of said first and second pressure equalizing means includes froth reduction means for reducing the creation of froth from said fluid therein.

11. The apparatus of claim 1, wherein said pressure equalizing means includes a housing and fluid level control means for maintaining the level of said filtrate within said housing at a predetermined level therein.

12. The apparatus of claim 11 or 9, wherein said liquid level control means comprises membrane means having a first surface and a second surface, said first surface of said membrane means being in contact with said housing, whereby said first surface of said membrane means is accessible to said fluid contained within said housing, said second surface of said membrane means being exposed to the atmosphere, said membrane means being gas permeable and fluid impermeable, whereby said fluid level within said housing can be controlled by the passage of gas through said membrane means.

13. The apparatus of claim 12, wherein said housing includes an outer wall including a window, and wherein said membrane means is contained within said window.

14. The apparatus of claim 13, wherein said outer wall of said housing including said window means is vertically disposed, and wherein said membrane means includes an upper end and a lower end, whereby said fluid level may be controlled substantially between said upper end and said lower end of said membrane means.

15. The apparatus of claim 12, wherein said membrane means is entirely enclosed within said housing.

16. The apparatus of claim 12, including membrane conduit means connecting said second surface of said membrane means to the atmosphere.

17. The apparatus of claim 16, wherein said membrane means is horizontally disposed within said housing.

18. The apparatus of claim 17, wherein said first surface of said membrane means is directed generally upwardly and wherein said second surface of said membrane means is directed generally downwardly.

19. The apparatus of claim 18, wherein said membrane conduit means extends generally vertically downwardly from said second surface of said membrane means, whereby any condensate formed within said membrane conduit means runs downwardly along said membrane conduit means and away from said membrane means.

20. The apparatus of claim 19, wherein said housing for said pressure equalizing means includes a fluid inlet at the upper end thereof, said fluid inlet being in fluid communication with said first conduit means.

21. The apparatus of claim 20, wherein said housing includes froth reduction means therein for reducing the creation of froth from said fluid between said fluid inlet and said membrane means.

22. The apparatus of claim 21, wherein said housing for said pressure equalizing means includes a fluid outlet at the lower end thereof, said fluid outlet being in fluid communication with said first conduit means.

23. The apparatus of claim 1, wherein said pressure equalizing means includes froth reduction means for reducing the creation of froth from said filtrate therein.

24. The apparatus of claim 1, including temperature measuring means for measuring the temperature of said filtrate flowing through said first conduit means.

25. A device for equalizing the pressure of a fluid flowing in a fluid conduit, said device comprising a housing in fluid communication with said fluid conduit, fluid level control means for maintaining the level of said fluid within said housing at a predetermined level therein, said liquid level control means comprising membrane means having a first surface and a second surface, said first surface of said membrane means being in contact with the inside of said housing, whereby said first surface of said membrane means is accessible to said fluid contained within said housing, said second surface of said membrane means being exposed to the atmosphere, said membrane means being gas permeable and fluid impermeable, whereby said fluid level can be controlled by the passage of gas through said membrane means, and condensate removal means for removal of any condensate formed relative to said second surface of said membrane means so as to prevent said condensate from interfering with said passage of said gas through said membrane means.

26. The apparatus of claim 25, wherein said condensate removal means includes membrane conduit means connecting said second surface of said membrane means to the atmosphere.

27. The apparatus of claim 26, wherein said membrane means is horizontally disposed within said housing.

28. The apparatus of claim 27, wherein said first surface of said membrane means is directed generally upwardly and wherein said second surface of said membrane means is directed generally downwardly.

29. The apparatus of claim 27, wherein said membrane conduit means extends generally vertically downwardly from said second surface of said membrane means, whereby any condensate formed within said membrane conduit means runs downwardly along said membrane conduit means and away from said membrane means.