Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition
First Claim
1. In a pharmaceutical depot composition for administration of at least one pharmacologically or immunologically active agent released slowly over an extended period of time at reasonably effective and predictable levels, which comprises a combination of(a) from 0.25% to 50% by weight of the composition of a pharmacologically or immunologically active agent in an effective depot amount greater than the single dose amount, and(b) a matrix which is minimally reactive towards body tissue and which is absorbable in the body over an extended period of time without adverse body reaction;
- the improvement comprising employing as said matrix an absorbable composition having a putty-like consistency at room and body temperatures, said matrix being completely free of fibrous materials, said matrix comprising between about 35% and 60% by weight of calcium stearate, between about 10% and about 35% by weight of dextran, the remainder of said matrix comprising castor oil.
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Abstract
An absorbable biologically compatible putty-like composition is used as a matrix from which immunologically or pharmacologically active agents, such as antibiotics, can be introduced into the body to provide a slow sustained release of the agent over an extended period of time. A preferred matrix comprises a mixture of calcium stearate, dextran and castor oil.
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Citations
13 Claims
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1. In a pharmaceutical depot composition for administration of at least one pharmacologically or immunologically active agent released slowly over an extended period of time at reasonably effective and predictable levels, which comprises a combination of
(a) from 0.25% to 50% by weight of the composition of a pharmacologically or immunologically active agent in an effective depot amount greater than the single dose amount, and (b) a matrix which is minimally reactive towards body tissue and which is absorbable in the body over an extended period of time without adverse body reaction; - the improvement comprising employing as said matrix an absorbable composition having a putty-like consistency at room and body temperatures, said matrix being completely free of fibrous materials, said matrix comprising between about 35% and 60% by weight of calcium stearate, between about 10% and about 35% by weight of dextran, the remainder of said matrix comprising castor oil.
- View Dependent Claims (3, 4, 6, 7, 12, 13)
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2. In a pharmaceutical depot composition for administration of at least one pharmacologically or immunologically active agent released slowly over an extended period of time at reasonably effective and predictable levels, which comprises a combination of
(a) from 0.25% to 50% by weight of the composition of a pharmacologically or immunologically active agent in an effective depot amount greater than the single dose amount, and (b) a matrix which is minimally reactive towards body tissue and which is absorbable in the body over an extended period of time without adverse body reaction; - said matrix comprising between about 38% and 42% of calcium stearate, between about 28% and 31% of spray dried dextran, and between 27% and 30% of castor oil, said composition having a putty-like consistency at room and body temperatures.
- View Dependent Claims (5)
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8. In a periodontal disease gum treating method for administration of at least one pharmacologically or immunologically active agent released slowly over an extended period of time at reasonably effective and predictable levels to infected or target area pockets between the base of a tooth and the adjoining periodontal tissues, which comprises a combination of
(a) from 0.25% to 50% by weight of the composition of a pharmacologically or immunologically active agent in an effective depot amount greater than the single dose amount, and (b) a matrix which is minimally reactive towards body tissue and which is absorbable in the body over an extended period of time without adverse body reaction; - the improvement comprising employing as said matrix, dispensed in the shape of a rod, pellet disc or tiny gum drop, to a pocket formed by teasing the gum away from the tooth, an absorbable composition having a putty-like consistency at room and body temperatures, said matrix being completely free of fibrous materials, said matrix comprising between about 35% and 60% by weight of calcium stearate, between about 10% and about 35% by weight of dextran, the remainder of said matrix comprising caster oil.
- View Dependent Claims (9, 10, 11)
Specification