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Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition

  • US 4,650,665 A
  • Filed: 10/28/1985
  • Issued: 03/17/1987
  • Est. Priority Date: 02/08/1985
  • Status: Expired due to Term
First Claim
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1. In a pharmaceutical depot composition for administration of at least one pharmacologically or immunologically active agent released slowly over an extended period of time at reasonably effective and predictable levels, which comprises a combination of(a) from 0.25% to 50% by weight of the composition of a pharmacologically or immunologically active agent in an effective depot amount greater than the single dose amount, and(b) a matrix which is minimally reactive towards body tissue and which is absorbable in the body over an extended period of time without adverse body reaction;

  • the improvement comprising employing as said matrix an absorbable composition having a putty-like consistency at room and body temperatures, said matrix being completely free of fibrous materials, said matrix comprising between about 35% and 60% by weight of calcium stearate, between about 10% and about 35% by weight of dextran, the remainder of said matrix comprising castor oil.

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