Oligonucleotide conjugates
First Claim
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1. A conjugate comprising an oligonucleotide covalently bonded to a carrier wherein said conjugate is a tolerogenic conjugate capable of inducing tolerance in a human patient suffering from SLE, comprising a heterogeneous DNA oligonucleotide at least 8 and not more than 500 base pairs in length covalently bonded to a non-antigenic, soluble isologous IgG immunoglobulin molecule, said covalent bonding being such that the conformation of said IgG immunoglobulin is similar enough to its natural conformation to render said conjugate tolerogenic rather than antigenic.
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Abstract
Conjugate composed of an oligonucleotide covalently bonded to a carrier.
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Citations
4 Claims
- 1. A conjugate comprising an oligonucleotide covalently bonded to a carrier wherein said conjugate is a tolerogenic conjugate capable of inducing tolerance in a human patient suffering from SLE, comprising a heterogeneous DNA oligonucleotide at least 8 and not more than 500 base pairs in length covalently bonded to a non-antigenic, soluble isologous IgG immunoglobulin molecule, said covalent bonding being such that the conformation of said IgG immunoglobulin is similar enough to its natural conformation to render said conjugate tolerogenic rather than antigenic.
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Current AssigneeChildren's Medical Center Corporation
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Original AssigneeChildren's Medical Center Corporation
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InventorsBorel, Yves, Stollar, B. David, Borel, Helina, Gallop, Paul M.
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Primary Examiner(s)Hazel, Blondel
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Application NumberUS06/524,298Time in Patent Office1,307 DaysField of Search260/112 R, 424/85, 424/88, 536/27-29, 435/91, 530/387US Class Current424/179.1CPC Class CodesA61K 31/70 Carbohydrates; Sugars; Deri...A61K 47/6807 the drug or compound being ...Y10S 530/868 involving autoimmunity, all...
