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Biologically active octapeptides

  • US 4,650,787 A
  • Filed: 04/25/1985
  • Issued: 03/17/1987
  • Est. Priority Date: 04/25/1985
  • Status: Expired due to Term
First Claim
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1. A compound of the formula ##STR39## wherein A is an L, D or DL amino acid selected from the group consisting of phenylalanine (Phe), its acetylated derivatives or a pharmaceutically acceptable acid addition salt thereof;

  • B is an L, D or DL amino acid selected from the group consisting of threonine amid (Thr NH2), tyrosine amide (Tyr NH2), tryptophan amide (Trp NH2);

    X is L-phenylalanine (L-Phe) or L-tyrosine (L-Tyr);

    Y is L-valine (L-Val);

    Z is D-tryptophan (D-Trp); and

    C" and C'"'"' are L or D-cysteine (Cys), -aminobutyric acid (Abu), aspartic acid (Asp) or lysine (Lys);

    provided that where C'"'"' is Cys, C" is also Cys and where C'"'"' or C" are other than Cys, C" is different from C'"'"' and is other than Cys;

    the connecting line between C" and C'"'"' signifies a bridge selected from the group consisting of carbon/carbon, carbon/sulfur, sulfur/sulfur and amide bridges; and

    the pharmaceutically acceptable acid addition salts thereof.

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