Magnetically-localizable, polymerized lipid vesicles and method of disrupting same
First Claim
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1. A method of delivering a therapuetic agent to a target site within the body, comprising the steps of:
- introducing ferromagnetic particle embedded vesicles containing said therapuetic agent into the blood stream upstream of said target site;
applying a magnetic field having sufficient strength to immobilize said vesicles at said target site;
immobilizing said vesicles at said target site; and
oscillating said magnetic field at a rate sufficient to vibrate said ferromagnetic particles such that said vesicles'"'"'s membrane is destabilized or lysed thereby controlling the rate of release of said therapuetic agent at said target site.
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Abstract
Polymerizable lipids are used to encapsulate therapeutic agents and ferronetic particles into lipid vesicles. The vesicles are polymerized, injected into the body upstream of a targeted capillary bed, allowed to flow within the bloodstream to the targeted site, and held there by an externally applied magnetic field. The magnetic field is oscillated at sufficient periodicity to destabilize or disrupt the vesicle membrane thus effecting a controlled release of the therapeutic agent.
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Citations
6 Claims
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1. A method of delivering a therapuetic agent to a target site within the body, comprising the steps of:
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introducing ferromagnetic particle embedded vesicles containing said therapuetic agent into the blood stream upstream of said target site; applying a magnetic field having sufficient strength to immobilize said vesicles at said target site; immobilizing said vesicles at said target site; and oscillating said magnetic field at a rate sufficient to vibrate said ferromagnetic particles such that said vesicles'"'"'s membrane is destabilized or lysed thereby controlling the rate of release of said therapuetic agent at said target site. - View Dependent Claims (2, 3, 4, 5, 6)
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Specification