Spectrophotometric method and apparatus for the non-invasive
First Claim
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1. A spectrophotometric apparatus for determining the glucose concentration in body tissues transcutaneously and non-invasively, comprising:
- (a) a directional optical light source located external to the body, the spectral composition of the beam of light from said source being such that it can penetrate the skin to tissues below;
(b) means for collecting light transmitted or diffusely reflected from said irradiated tissue;
(c) means for detecting and converting into electrical signals light gathered from at least one band with a measuring signal wavelength λ
G of 1575, 1765, 2100 or 2270 + or - 15 nm, typical of the glucose absorption spectrum, and at least one band with a reference signal wavelength λ
R in the range of 1000 to 2700 nm, typical of the absorption spectrum of background tissue containing glucose but in which the absorption of glucose is nil or insignificant; and
(d) means for transforming said electrical signals into data representing glucose determinations.
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Abstract
A directive light beam in a wavelength range appropriate for penetrating into body tissues is applied to a portion of a patient'"'"'s body and the energy transmitted or back-scattered by the underlying tissue is analyzed spectrophotometrically for the presence of glucose. Analysis is performed using especially selected bands in the near-infrared region.
787 Citations
9 Claims
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1. A spectrophotometric apparatus for determining the glucose concentration in body tissues transcutaneously and non-invasively, comprising:
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(a) a directional optical light source located external to the body, the spectral composition of the beam of light from said source being such that it can penetrate the skin to tissues below; (b) means for collecting light transmitted or diffusely reflected from said irradiated tissue; (c) means for detecting and converting into electrical signals light gathered from at least one band with a measuring signal wavelength λ
G of 1575, 1765, 2100 or 2270 + or - 15 nm, typical of the glucose absorption spectrum, and at least one band with a reference signal wavelength λ
R in the range of 1000 to 2700 nm, typical of the absorption spectrum of background tissue containing glucose but in which the absorption of glucose is nil or insignificant; and(d) means for transforming said electrical signals into data representing glucose determinations. - View Dependent Claims (2, 3, 4)
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5. A spectrophotometric method for the transcutaneous, non-invasive determination of glucose concentrations in body tissues, comprising the steps of:
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(a) irradiating a selected body portion with light from a directional optical lamp source; (b) collecting the resulting luminous energy (I) either transmitted or diffusively reflected by a sample volume of body tissue under the skin of said irradiated body portion, said collected light including at least one band with a measuring signal wavelength λ
G of 1575, 1765, 2100 or 2270 + or - 15 nm, typical of the glucose absorption spectrum, and at least one band with a reference signal wavelength λ
R in the range of 1000 to 2700 nm, typical of the absorption spectrum of background tissue containing glucose but in which the absorption of glucose is nil or insignificant;(c) converting said collected light into electrical signals IG and IR representing said measuring and reference bands, respectively; and (d) entering said electrical signals into an electronic computer for transformation into glucose concentrations. - View Dependent Claims (6, 7, 8, 9)
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Specification