Intra-peritoneal perfusion of oxygenated fluorocarbon

• US 4,657,532 A
• Filed: 07/19/1985
• Issued: 04/14/1987
• Est. Priority Date: 07/19/1985
• Status: Expired due to Term

• Current Assignee: Thomas Jefferson University 11TH and Walnut Streets Philadelphia PA 19107
• Original Assignee: Thomas Jefferson University (Main Line Health System)
• Inventors: Osterholm, Jewell L.
• Primary Examiner(s): NOT, DEFINED
• Assistant Examiner(s): Smith, Jr., Jerome R.
• Application Number:
  US06/757,015
• Time in Patent Office: 634 Days
• Field of Search: 604/23-29, 604/51, 604/52, 514/10, 128/632, 514/755
• US Class Current: 604/24
• CPC Class Codes: A61K 31/34 having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
• CPC Class Codes: A61K 9/0026 Blood substitute; Oxygen transporting formulations; Plasma extender
• CPC Class Codes: A61M 1/287 Dialysates therefor
• CPC Class Codes: A61M 1/32 Oxygenators without membranes
• CPC Class Codes: A61M 2202/0476 Oxygenated solutions
• CPC Class Codes: A61P 7/08 Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock artificial tears A61P27/04

Abstract

A novel method of oxygenating the tissue of a living mammal is disclosed comprising the steps of providing an oxygenated fluorocarbon-containing liquid; injecting that oxygenated liquid into the peritoneal cavity of said mammal; and withdrawing said fluorocarbon liquid from said cavity, said injecting and withdrawing be conducted at a rate sufficient to oxygenate said tissue. Accordingly, a novel "artificial lung" is disclosed which is useful to selectively oxygenate the body of a mammal, as reflected by increased arterial blood gas (pO₂) in said mammal.

Claims

1. A method of oxygenating the tissue of a living mammal, comprising the steps of:

(a) providing an oxygenated fluorocarbon containing liquid;

(b) injecting said oxygenated fluorocarbon liquid into the peritoneal cavity of said mammal;

(c) withdrawing said liquid from said cavity;

said injecting and withdrawing being conducted at a rate sufficient to oxygenate at least a portion of the tissue of said mammal, said rate being at least about 20 milliliters per minutes per kilogram of body weight of said mammal.

2. The method of claim 1 wherein said rate is about 25 milliliters per minute per kilogram of body weight of said mammal.