Ultrasonically modulated polymeric devices for delivering compositions

• US 4,657,543 A
• Filed: 07/23/1984
• Issued: 04/14/1987
• Est. Priority Date: 07/23/1984
• Status: Expired due to Term

• Current Assignee: Massachusetts Institute of Technology
• Original Assignee: Massachusetts Institute of Technology
• Inventors: Langer, Robert S., Kost, Joseph
• Primary Examiner(s): Truluck, Dalton L.
• Assistant Examiner(s): Costantino, Mario
• Application Number:
  US06/633,366
• Time in Patent Office: 995 Days
• Field of Search: 604/890-897, 604/285, 604/49, 604/93, 604/290, 604/28, 604/22, 128/24 A, 128/328, 128/804, 204/157.15, 204/157.62
• US Class Current: 424/486
• CPC Class Codes: A61K 41/0047 Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/2027 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: A61K 9/2031 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: C08G 67/04 Polyanhydrides

Abstract

A composition such as a biologically active substance is delivered upon demand from a polymeric matrix by exposing the polymeric matrix containing the composition to ultrasonic energy.

Claims

1. A process for delivering a biologically active substance on demand comprising the steps of:

combining a biologically active substance with a biocompatible polymeric composition as an admixture;

forming said admixture into a shaped, solid polymeric matrix;

implanting said solid polymeic matrix in-vivo at a preselected site such that said solid implanted matrix is in a liquid environment; and

exposing said implanted solid polymeric matrix to ultrasonic energy for a predetermined time to effect cavitation of said solid polymeric matrix by rapid compression with subsequent expansion of liquid or solid surrounding said solid polymeric matrix thereby to control the rate of release of said biologically active substance from said matrix over a specific time period wherein the rate of release is changed during said time period.

2. The process of claim 1 wherein said exposure to ultrasonic energy degrades said polymeric matrix.

3. The process of claim 1 wherein said polymeric matrix is a polyanhydride.

4. The process of claim 1 polymeric matrix is a copolymer of ethylene and vinyl acetate.

5. The process of claim 1 wherein said biologically active substance is a drug.

6. The process of claim 1 wherein said biologically active composition is insulin.