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Microbubble precursors and apparatus for their production and use

  • US 4,657,756 A
  • Filed: 09/08/1983
  • Issued: 04/14/1987
  • Est. Priority Date: 11/17/1980
  • Status: Expired due to Term
First Claim
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1. A sterile injectable fluid composition of matter in unit dosage form and adapted for injection into the blood stream of a living being and generating microbubbles therein, comprising a suspension of (a) a particulate solid which is a non-toxic, physiologically acceptable material, soluble in blood and substantially free of microbubbles, whose particles are aggregates having gas filled voids therebetween of smaller particles having an average size in the range of from 1 to 250 micrometers, with the ratio of the mass of the smaller particles to the volume of gas in the voids therebetween effective to render blood in which the composition of matter is dissolved supersaturated with respect to the gas in the area of the blood surrounding the microbubbles when they form therein, in (b) an amount of a carrier liquid which is non-toxic and physiologically acceptable and in which the particulate material is at least temporarily stable.

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