Dental rinse

• US 4,657,758 A
• Filed: 01/27/1984
• Issued: 04/14/1987
• Est. Priority Date: 01/27/1984
• Status: Expired due to Term

• Current Assignee: Pfizer Inc.
• Original Assignee: Oral Research Laboratories Incorporated
• Inventors: Berger, Richard, Lazare, Allan J., Goldemberg, Robert L.
• Primary Examiner(s): Rose, Shep K.
• Application Number:
  US06/574,350
• Time in Patent Office: 1,173 Days
• Field of Search: 424/49-58
• US Class Current: 424/49
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 8/368 with carboxyl groups directly bound to carbon atoms of aromatic rings
• CPC Class Codes: A61K 8/39 Derivatives containing from 2 to 10 oxyalkylene groups
• CPC Class Codes: A61K 8/44 Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
• CPC Class Codes: A61K 8/463 containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

This invention relates to improved oral compositions for dental hygiene, and, in particular, to dental rinse formulations which upon application to the teeth, loosen plaque present on dental surfaces and render it more amenable to removal during brushing with a conventional dentifrice.

Claims

1. A method for loosening and removing plaque present on dental surfaces comprising rinsing said dental surfaces with a dental rinse composition, wherein the dental rinse composition comprises an aqueous or an aqueous and alcoholic orally compatible carrier for the ingredients of said dental rinse composition, wherein said ingredients include:

about 0.1 to about 10% by weight of said dental rinse composition of an oral surfactant, at least about 1% by weight of said composition of sodium benzoate effective to increase the amenability of said plaque to removal, said composition including an effective amount of a detergent builder, and having a pH of about 7.5 to about 10; and

said method further comprising the step of brushing the dental surfaces to which said dental rinse has been previously applied.

2. The method according to claim 1 wherein the carrier for the ingredients of said composition is alcohol and water, and the pH of said dental rinse composition is about 7.5 to about 9.0.

3. The method of claim 1 wherein the oral surfactant comprises about 0.5 to about 2% by weight of said dental rinse composition, and wherein said dental rinse includes at least about 2% of sodium benzoate.

4. The method according to claim 3 wherein the surfactant is an anionic oral surfactant.

5. The method of claim 1 wherein the oral surfactant is selected from the group consisting of orally acceptable surface active sulfonated monoglycerides of fatty acids having about 10 to about 18 carbon atoms, alkyl sulfonates, block polymers of polyoxyethylene and polyoxypropylene, N-methyl-N-palmitoyl tauride, sodium N-lauroyl sarcosinate and mixtures of the foregoing.

6. The method according to claim 1 wherein the carrier further includes as said detergent builder an effective amount of a compound or mixtures thereof selected from the group consistiing of orally compatible borate, carbonate or bicarbonate detergent builders in addition to said sodium benzoate.

7. The method according to claim 1 wherein the solution comprises about 0.1 to 1% by weight of sodium borate.

8. The method according to claim 6 wherein said sodium benzoate comprises at least about 2% by weight of said composition.

9. The method accordingto claim 1 wherein the composition comprises about 0.1% to about 1.0% by weight of sodium bicarbonate.

10. The method according to claim 4 wherein said composition comprises by weight at least 2% sodium benzoate and about 0.1% to about 1% by weight of detergent builder which is sodium bicarbonate, sodium borate or mixtures thereof.

11. The method according to claim 1 wherein said detergent builder comprises about 0.1% to 1% sodium borate and about 0.3% to about 0.8% of sodium bicarbonate, and at least about 2% by weight of sodium benzoate.

12. The method according to claim 1 wherein said rinsing and then brushing steps are repeated twice a day over a seven day period, said composition being effective over said seven day period to remove at least about 10% of the surface area of plaque initially present on said dental surfaces.

13. The method according to claim 1 wherein said rinsing and then brushing steps are repeated twice a day over a seven day period, said method being effective over said seven day period to remove at least about 50% of the surface area of plaque initially present on said dental surfaces.

14. The method according to claim 1 wherein the aqueous solution includes an effective amount of sodium salicylate.

15. The method according to claim 1 wherein said composition includes about 0.1% to 3% of said sodium salicylate.

16. The method according to claim 6 wherein said composition includes an effective amount of sodium salicylate.

17. The method according to claim 1 wherein the composition further includes an effective amount of a wound healing agent.

18. The method according to claim 17 wherein said wound healing agent is allantoin.

19. The method according to claim 1 wherein said composition comprises by weight about 2% sodium benzoate and about 0.1% to 3% sodium salicylate effective to aid in solubilizing plaque on said dental surfaces.

20. The method according to claim 1 wherein said carrier comprises about 65% ot about 95% water and about 5% to about 35% ethanol, and said ingredients of said composition are dissolved therein.

21. The method according to claim 1 wherein the composition is comprised of a solvent of alcohol and water, about 0.5% to about 2% of an oral surfactant, about 0.1% to about 1% of sodium borate, about 0.3% to about 0.8% sodium bicarbonate, and at least about 2% of sodium benzoate.

22. The method according to claim 1 wherein said composition further includes up to about 20% by weight of glycerine, allantoin, and about 0.1% to about 3% by weight of sodium salicylate.

23. The method according to claim 1 wherein said composition comprises at least about 2% sodium benzoate, about 0.1% to about 1% sodium bicarbonate, about 0.1% to about 1% sodium borate, up to about 20% by weight of glycerine, about 0.1% to about 3% sodium salicylate, and wherein said carrier comprises about 70% to 95% of said composition and said carrier is comprised of about 65% to about 95% water and about 5% to about 35% ethanol, said composition further including allantoin, xanthan gum, and minor effective amounts of flavorant.

24. The method according to claim 1 wherein the carrier is comprised of alcohol and water, the dental rinse includes at least about 2% sodium benzoate, and said dental rinse has a pH of about 7.5.