Pharmaceutical composition

• US 4,657,901 A
• Filed: 09/07/1984
• Issued: 04/14/1987
• Est. Priority Date: 09/07/1983
• Status: Expired due to Fees

• Current Assignee: Shiseido Company Limited
• Original Assignee: Sheiseido Company Limited, Takeda Chemical Industries, Ltd. (Takeda Pharmaceutical Company Limited)
• Inventors: Fukuda, Minoru, Toyoda, Hidekazu, Ueda, Haruhiko
• Primary Examiner(s): NOT, DEFINED
• Assistant Examiner(s): Lipovsky, Joseph A.
• Application Number:
  US06/648,276
• Time in Patent Office: 949 Days
• Field of Search: 514/171, 424/81, 260/397.4
• US Class Current: 514/171
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/05 Phenols cannabinoids A61K31/658
• CPC Class Codes: A61K 31/17 having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine isoureas, isothioureas A61K31/155; sulfonylureas A61K31/64
• CPC Class Codes: A61K 31/565 not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol

Abstract

The present invention concerns a composition for topical application which is greatly useful for the treatment of acne. The composition contains (1) a compound of the formula: ##STR1## or its ester or ether, (2) keratolytic agent and (3) pharmaceutically acceptable carrier.

Claims

1. A composition for the topical treatment of acne, which comprises

(1) an effective amount for treating acne of oxendolone or its ester or ether, (2) a keratolytic agent, and (3) a pharmaceutically acceptable carrier.

2. The composition according to claim 1, wherein the content of oxendolone is from about 0.001 W/V % to about 2 W/V % relative to the whole composition.

3. The composition according to claim 1, wherein the keratolytic agent is urea.

4. The composition according to claim 1, wherein the keratolytic agent is resorcinol.

5. The composition according to claim 1 wherein the oxendolone is from about 0.001 W/V % to about 2 W/V % relative to the whole composition and the keratolytic agent is present in an amount of 0.001 to about 15 W/V %.

6. The composition according to claim 1 which contains a gelling agent in an amount of 0.001 to about 20 W/V % and an alcohol in an amount of 5 to 70 W/V %.

7. The composition according to claim 1, wherein the composition comprises a gelling agent and/or an alcohol.

8. The composition according to claim 7, wherein the gelling agent is carboxyvinyl polymer.

9. The composition according to claim 7, wherein the alcohol is ethyl alcohol.

10. The composition according to claim 7, wherein the alcohol is benzyl alcohol.

11. The composition according to claim 7, which comprises oxendolone, urea, carboxyvinyl polymer, ethyl alcohol and benzyl alcohol.

12. The composition according to claim 7, which comprises oxendolone, resorcinol, carboxyvinyl polymer, ethyl alcohol and benzyl alcohol.

13. The composition according to claim 7, wherein the content of the oxendolone is from about 0.001 W/V % to about 2 W/V % relative to the whole composition.

14. The composition according to claim 7, wherein the keratolytic agent is urea.

15. The composition according to claim 7, wherein the heratolytic agent is resorcinol.

16. A method of treatment of acne which comprises administering topically the composition containing

(1) an effective amount for treating acne of oxendolone, or its ester or ether,

(2) a keratolytic agent, and

(3) a pharmaceutically acceptable carrier.

17. A method according to claim 16 wherein the oxendolone is present in an amount of from about 0.001 W/V % to about 2 W/V % relative to the whole composition and the keratolytic agent is present in an amount of 0.001 to about 15 W/V %.

18. A method according to claim 17 which contains a gelling agent in an amount of 0.001 to about 20 W/V % and an alcohol in an amount of 5 to 70 W/V %.