Eye rod, process and apparatus for loading the same with solutions or suspensions of active substance

• US 4,659,584 A
• Filed: 04/11/1986
• Issued: 04/21/1987
• Est. Priority Date: 04/13/1985
• Status: Expired due to Fees

• Current Assignee: Dr. Karl Thomae GmbH (C.H. Boehringer Sohn AG & Co. KG)
• Original Assignee: Dr. Karl Thomae GmbH (C.H. Boehringer Sohn AG & Co. KG)
• Inventors: Schilk, Leonhard
• Primary Examiner(s): Lusignan, Michael R.
• Application Number:
  US06/851,009
• Time in Patent Office: 375 Days
• Field of Search: 118/669, 118/671, 118/672, 118/674, 118/679, 118/691, 427/2, 604/289, 604/893
• US Class Current: 604/294
• CPC Class Codes: A61F 9/0008 Introducing ophthalmic products into the ocular cavity or retaining products therein putting in contact lenses A61F9/0061; introducing or retaining media in cavities of the body in general A61M31/00
• CPC Class Codes: A61J 3/00 Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms

Abstract

The specification describes a process and apparatus for charging eye rods with solutions or suspensions of active substance. The latter are applied dropwise, by means of a micrometering device, to specific points on the eye rods which are set in rotation, and simultaneously or subsequently the solvent or suspension agent is removed.

Claims

1. A process for loading eye rods with a solution or suspension of active substance, said process comprising the steps of applying said solution or suspension of active substance, in the form of droplets of constant volume, with the aid of a micrometering device which always releases the same number of droplets to each eye rod, onto the intended zones of each of said eye rods, rotating each of said eye rods in order to distribute said solution or suspension over said zone and removing the solvent or suspension agent by evaporation, so as to leave the dried active substance on each of said eye rods.

2. An apparatus for loading eye rods with a solution or suspension of active substance, said apparatus comprising a micrometering system for applying droplets of said solution or suspension to each of said eye rods;

a drying apparatus for evaporating the solvent or suspension agent from said solution or suspension applied to said eye rods;

a first straight or curved belt, driven in a first direction, for conveying said eye rods past said micrometering system and said drying apparatus; and

a second, counter rotating, straight or curved belt, which works in conjunction with said first belt in order to cause the rotation of eye rods being conveyed by said first belt.

3. The apparatus of claim 2, further characterized in that said first and second belts are horizontal conveyor belts arranged one above the other in spaced-apart, parallel relationship;

and wherein said apparatus further comprises an endless roller chain which is caused by the relative motions of said first and second belts to move in the direction of said first belt, said roller chain having spaces between transverse links thereof which are adapted to receive eye rods and said roller chain serving to retain said eye rods in a spaced-apart, parallel relationship as they are conveyed;

a drying tunnel, arranged along said belts, through which said eye rods are conveyed and through which hot air from a drying blower is passed in order to evaporate solvent or suspension agent from said eye rods;

a storage area from which eye rods are delivered to said first belt; and

a delivery station at which eye rods are removed from said first belt.

4. The apparatus of claim 3, further characterized in that said first and second conveyor belts are narrower than said roller chain and said drying tunnel is fitted over a freely accessible part of the roller chain in such a way that tips of eye rods charged with solution or suspension pass through said drying tunnel.

5. The apparatus of claim 2 wherein said first belt is a conveyor wheel driven in a first direction and having notches or recesses for receiving eye rods on the outside surface thereof, said second belt being positioned so as to abut said conveyor wheel between an input point and an exit point, and wherein said drying apparatus comprises a drying blower connected to a drying tunnel through which the zone of each of said eye rods loaded with solution or suspension is passed.

6. An eye rod, for administering an active substance to the eye, comprising a rod-like member having on the outer surface thereof a dry coating of said active substance, said coating of active substance being confined to a band extending from a point proximate to, but not including, one end of said rod-like member.

7. A process for loading an eye rod with an active substance, said process comprising the steps of:

(a) applying a predetermined number of droplets of a predetermined volume of a solution or suspension of said active substance to an intended zone of said eye rod,

(b) simultaneously or subsequently rotating said eye rod about its longitudinal axis, in order to uniformly distribute said solution or suspension on the surface of said eye rod in said zone, and

(c) then removing the solvent or suspension agent by evaporation in order to leave dried active substance on said eye rod.

8. A device for loadng eye rods with active substance, said device comprising:

(a) means for conveying a plurality of eye rods along a motion path in a spaced-apart, substantially parallel relationship;

(b) means located at a point along said motion path for applying a predetermined number of droplets of a predetermined volume of a solution or suspension of active substance to an intended zone of each eye rod conveyed past said point on said motion path;

(c) means for rotating each eye rod being conveyed along said motion path about its longitudinal axis, in order to uniformly distribute the solution or suspension of active substance applied to said eye rod on the surface thereof in said intended zone; and

,

(c) means for evaporating the solvent or suspension agent from the charge of active substance which has been applied to each eye rod, as said eye rod moves along said motion path, in order to leave dried active substance on said eye rod.

9. The device of claim 8 wherein said means for conveying said eye rods along said motion path comprises a first conveyor belt driven in a first direction at a first speed and wherein said means for rotating said eye rods comprises a second conveyor belt driven in a second direction opposite to that of the first and at a second speed which is less than that of the first, said second belt being in a spaced-apart, parallel relationship to said first belt, the distance between said two belts being such that eye rods placed upon said first belt are contact by said second belt.

10. The device of claim 9 further comprising an endless roller chain which is conveyed along said motion path and which has spaces between transverse links thereof adapted to receive eye rods therein, said roller chain serving to maintain said eye rods in a spaced-apart, substantially parallel relationship.

11. The device of claim 8 wherein said means for conveying said eye rods comprises a conveyor wheel having notches or recesses on its outer surface for receiving eye rods and means for rotatingly driving said wheel in a first direction and wherein said means for rotating said eye rods comprises a belt, driven in a direction opposite to that of said first direction, which contacts eye rods being conveyed by said conveyor wheel.