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Support for solid-phase oligonucleotide synthesis

  • US 4,659,774 A
  • Filed: 11/01/1985
  • Issued: 04/21/1987
  • Est. Priority Date: 11/01/1985
  • Status: Expired due to Fees
First Claim
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1. A polymer support/nucleoside-linker composite having the general formula


  • space="preserve" listing-type="equation">P'"'"'--S'"'"'
wherein P'"'"' is a polymer support which bears oxirane, aziridine or episulfide groups;

S'"'"' is a nucleoside-linker having the general formula


space="preserve" listing-type="equation">W--(CH.sub.2).sub.a --X--(CH.sub.2).sub.b --Y--(CH.sub.2).sub.c --Zwherein W and Z each independently comprise a nucleophile selected from the group consisting of amine, alcohol and thio groups;

X and Y, which independently may or may not be present, comprise groups of high hydrophilicity; and

a, b, c are integers from 0 to 9, where a plus b plus c exceeds 6;

wherein P'"'"' is conjugated through a carbon thereof to S'"'"' by means of a covalent bond with either of said nucleophile W or Z.

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