Dialysis instrument with dialysate side pump for moving body fluids

• US 4,661,246 A
• Filed: 10/01/1984
• Issued: 04/28/1987
• Est. Priority Date: 10/01/1984
• Status: Expired due to Term

• Current Assignee: HemoCleanse Technologies LLC (HemoCleanse, Inc.)
• Original Assignee: ASH Medical Systems Incorporated
• Inventors: Ash, Stephen R.
• Primary Examiner(s): Fisher, Richard V.
• Assistant Examiner(s): Jones, W. Gary
• Application Number:
  US06/656,314
• Time in Patent Office: 939 Days
• Field of Search: 210/87, 210/94, 210/110, 210/134, 210/189, 210/195.2, 210/257.2, 210/266, 210/295, 210/321.2, 210/321.3, 604/67
• US Class Current: 210/87
• CPC Class Codes: A61M 1/1692 Detection of blood traces in dialysate
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/267 used for pumping
• CPC Class Codes: A61M 1/30 Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
• CPC Class Codes: A61M 1/306 Pressure control, e.g. using substantially rigid closed or gas buffered or elastic reservoirs
• CPC Class Codes: A61M 1/308 Volume control, e.g. with open or flexible containers, by counting the number of pump revolutions, weighing
• CPC Class Codes: A61M 1/309 with trans-membrane pressure [TMP] increasing substantially continuously during arterial phase
• CPC Class Codes: A61M 1/3493 using treatment agents in suspension
• CPC Class Codes: A61M 1/3626 Gas bubble detectors
• CPC Class Codes: A61M 1/3663 Flow rate transducers; Flow integrators
• CPC Class Codes: A61M 2205/123 with incorporated reservoirs
• CPC Class Codes: A61M 2205/126 with incorporated membrane filters
• CPC Class Codes: A61M 2205/50 with microprocessors or computers

Abstract

A dialysis instrument having a pump located on the dialysate side of a dialyzer for moving body fluids. A disposable cartridge mounted to a main frame includes containers of calcium chloride, priming solution, water, sorbent column, dialysate reservoir bag and potassium/hydrogen citrate reinfusate reservoir. A plurality of monitors detect the status of the flow of fluids and process of dialysis and provide data for the operation of a plurality of pumps and clamps to control the direction of flow of various fluids. The entire instrument is mounted on a scale to detect weight change due to the difference between inflow and outflow of body fluids.

Claims

1. A single access dialysis instrument, comprising:

a single catheter for transmission of body liquids to and from the body;

a reciprocating dialyzer with dialyzer membranes and having body liquid side disposed within said dialyzer membranes including means for defining a body fluid inlet and a body fluid outlet connected to said catheter, said reciprocating dialyzer further having a dialysate side disposed outside said dialyzer membranes including means for defining a dialysate inlet and a dialysate outlet, said body liquid side and said dialysate side separated by said dialyzer membranes, said dialyzer membranes being compliantly formed to expand and contract in response to a corresponding change in pressure between said body liquid and said dialysate within said dialyzer;

storage means connected to said dialysate inlet and said dialysate outlet for holding a supply of liquid including dialysate for use in said dialyzer; and

,

dialyzer control means for controlling the inflow and outflow of body liquid and dialysate to and from said dialyzer in a reciprocating cyclic fashion while maintaining said dialysate within said dialysate side of said dialyzer at a non-elevated pressure throughout the entire cycle of said dialyzer, said dialyzer control means further for maintaining a positive pressure gradient from said body liquid side to said dialysate side throughout the reciprocating cycle of said dialyzer.

2. The instrument of claim 1 wherein said dialyzer control means includes a dialysate pump communicating with said dialysate inlet and dialysate outlet of said dialyzer and operable to pump dialysate between said storage means and said dialysate side of said dialyzer.

3. The instrument of claim 2 wherein said dialyzer control means further includes a liquid flow control means having clamps associated with said body fluid inlet, said body fluid outlet, and said dialysate inlet to control flow there through, said liquid flow control means for controlling the flow of body liquid and dialysate to and from said dialyzer by operation of said clamps in association with said dialysate pump.

4. The instrument of claim 3 wherein said storage means is a disposable assembly including:

a dialysate reservoir container for holding a quantity of water and defining an outflow port connected to said dialysate inlet and an inflow port connected to said dialysate outlet through said dialysate pump.

5. The instrument of claim 4 wherein said storage means further includes:

a sorbent column to regenerate dialysate and for holding dialysate and body liquid side components for eventual disposal, said column being connected between and in fluid communication with said dialysate inlet and said dialysate outlet.

6. The instrument of claim 5 wherein said storage means further includes:

a reinfusate reservoir having chemicals therein being in fluid communication with said dialysate reservoir to supply said chemicals into said dialysate for the replenishment thereof.

7. The instrument of claim 6 and further comprising:

a body liquid infusate container connected between and to said catheter and said dialyzer.

8. The instrument of claim 1 and further comprising:

priming means connected to said body liquid side and in fluid communication with said dialyzer to hold a priming liquid being operable to provide liquid thereto to prime said dialyzer.

9. The instrument of claim 1 and further comprising:

monitoring means operably associated with said body fluid inlet and said body fluid outlet and having light detecting means operable to detect flow parameters of blood passing through said body fluid inlet and said body fluid outlet including detection of bubbles, clots and particles present therein.

10. The instrument of claim 9 and further comprising:

a container of a salt of citrate connected to said dialysate inlet.

11. The instrument of claim 10 and further comprising:

a disposable cartridge having said dialyzer, said storage means and said container of a salt of citrate mounted thereon; and

,

a sorbent column mounted on said disposable cartridge and connected between said dialysate inlet and said dialysate outlet to remove impurities from said dialysate.

12. The instrument of claim 1 and further comprising:

weight measuring means associated with said dialyzer and said storage means for measuring changes in the weight of the machine due to withdrawal and return of body liquid through said catheter and due to ultrafiltration of fluid across said dialyzer.

13. The instrument of claim 1 and further comprising:

measurement means connected to said body liquid side of said dialyzer for instantaneously measuring body liquid flow into said dialyzer.