Dispenser comprising telescopically engaging members

• US 4,663,148 A
• Filed: 02/14/1986
• Issued: 05/05/1987
• Est. Priority Date: 03/21/1984
• Status: Expired due to Fees

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Eckenhoff, James B., Theeuwes, Felix, Deters, Joseph C.
• Primary Examiner(s): Rose, Shep K.
• Application Number:
  US06/829,633
• Time in Patent Office: 445 Days
• Field of Search: 604/890, 424/14, 424/19, 424/20, 424/21, 424/22, 424/37, 424/38
• US Class Current: 424/454
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

A dispenser is disclosed for delivering a beneficial agent to an environment of use. The dispenser comprises a semipermeable wall surrounding a compartment containing a heat responsive composition, and an expandable composition. A passageway in the wall connects the compartment with the exterior of the dispenser.

Claims

1. A dispenser for dispensing a beneficial drug composition to a biological environment of use, wherein the dispenser comprises:

(a) a container comprising a telescopically engaging gelatin cap and body;

(b) a composition in the container, which composition comprises a beneficial drug and a temperature sensitive means for forming a dispensable composition in a biological environment having a temperature up to 40°

C., said means a member selected from the group consisting of a butter, wax, stearate, hydrogenated oil, partially hydrogenated oil, glyceride, glycol, ester and polyether;

(c) means in the container for occupying an increasing volume in the compartment for pushing the dispensable composition from the dispenser, said means a hydrophilic hydrogel composition that interacts with fluid and exhibits a 2 to 50 volume increase in the presence of fluid that enters the container;

(d) a wall surrounding the container, the wall comprising at least in part a semipermeable composition comprising a cellulose acylate, cellulose diacylate, cellulose triacylate, cellulose ester and cellulose ether composition permeable to fluid present in the environment of use; and

(e) at least one passageway in the disperser for dispensing the dispensable composition from the dispenser.