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Dispenser comprising inner and outer walls functioning as cooperative unit

  • US 4,663,149 A
  • Filed: 02/14/1986
  • Issued: 05/05/1987
  • Est. Priority Date: 03/21/1984
  • Status: Expired due to Term
First Claim
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1. A dispenser for delivering a beneficial drug to a biological environment of use, wherein the dispenser comprises:

  • (a) a wall comprising in at least a part a semipermeable composition permeable to the passage of fluid and substantially impermeable to the passage of a beneficial drug, which wall surrounds;

    (b) a pharmaceutically acceptable single-piece capsule;

    (c) means in the capsule for absorbing heat from the biological environment for forming a dispensable composition, which means exhibits storable properties up to 32°

    C. and becomes at least one of fluid, semisolid and viscous at a temperature of 32°

    C. to 40°

    C. thereby providing a dispensable composition;

    (d) a beneficial drug housed in the means for absorbing heat from the biological environment, said drug producing at least one of a local and systemic effect when the dispenser is in operation in the biological environment;

    (e) means in the capsule for urging the means for absorbing heat comprising the beneficial drug from the dispenser, said urging means at least one of a member selected from the group consisting of an expandable acrylate, pyrrolidone, anionic hydrogel, cationic hydrogel, polyelectrolyte, cellulosic, polysaccharide, carboxypolymer, acrylamide, polyalkylene oxide, starch, and vinyl lactam; and

    ,(f) at least one orifice in the dispenser for delivering the beneficial drug composition from the dispenser.

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