Method and composition for hepatitis treatment with pyrimidine nucleoside compounds
First Claim
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1. A method for the treatment of hepatitis B virus infection in an infected human comprisingadministering an effective amount to inhibit hepatitis B virion replication, 5-substituted-1-(2'"'"'-deoxy-2'"'"'-substituted-beta-D-arabinofuranosyl)pyrimidine compound of the formula ##STR1## wherein A is OR3, SR3, NR3 R4 or NHacyl wherein R3 and R4 are the same or different and are hydrogen, lower alkyl of 1 to 7 carbon atoms, aralkyl, or aryl;
- NHacyl is alkanoyl or aroyl amide;
B is oxygen or sulfur;
X is halogenY is halogen, amino, monoalkyl- or monoaralkylamino, dialkylamino, aminomethyl, hydroxymethyl, lower alkyl, aryl, aralkyl, vinyl and substituted vinyl or ethynyl and substituted ethynyl;
Z is methyne or nitrogen;
R1 and R2 are the same or different and are hydrogen acyl or aroyl.
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Abstract
The invention relates to 5-substituted-1-(2'"'"'-deoxy-2'"'"'-substituted-beta-D-Arabinofuranoysyl) pyrimidine compounds and their use in a method for the treatment of hepatitis B viruses.
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Citations
9 Claims
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1. A method for the treatment of hepatitis B virus infection in an infected human comprising
administering an effective amount to inhibit hepatitis B virion replication, 5-substituted-1-(2'"'"'-deoxy-2'"'"'-substituted-beta-D-arabinofuranosyl)pyrimidine compound of the formula ##STR1## wherein A is OR3, SR3, NR3 R4 or NHacyl wherein R3 and R4 are the same or different and are hydrogen, lower alkyl of 1 to 7 carbon atoms, aralkyl, or aryl; -
NHacyl is alkanoyl or aroyl amide; B is oxygen or sulfur; X is halogen Y is halogen, amino, monoalkyl- or monoaralkylamino, dialkylamino, aminomethyl, hydroxymethyl, lower alkyl, aryl, aralkyl, vinyl and substituted vinyl or ethynyl and substituted ethynyl; Z is methyne or nitrogen; R1 and R2 are the same or different and are hydrogen acyl or aroyl. - View Dependent Claims (2, 3, 9)
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- 4. A method of treating hepatitis B virus infection comprising administering an effective amount of FIAC.
- 6. A method of treating hepatitis B virus infection comprising admininstering an effective amount of FMAU.
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8. A method of treating hepatitis B virus infection comprising administering an effective amount of FIAU.
Specification