Implantable hand-operable dispensers for fluid medicaments

• US 4,668,231 A
• Filed: 01/31/1985
• Issued: 05/26/1987
• Est. Priority Date: 02/15/1984
• Status: Expired due to Term

• Current Assignee: NMT NeuroSciences (International), Inc.
• Original Assignee: Cordis Corporation (Cardinal Health, Inc.)
• Inventors: de Vries, Gerrit, Leuveld, Jozef G. M., Kleijn, Johan W.
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): Kartchner, Gene B.
• Application Number:
  US06/696,772
• Time in Patent Office: 845 Days
• Field of Search: 604/8-10, 604/175, 604/181, 604/183, 604/185, 604/186, 604/891, 604/151-153, 604/141
• US Class Current: 604/891.1
• CPC Class Codes: A61M 5/1428 with manual pumping action

Abstract

YA hand-operable dispenser for fluid medicaments is provided in a form which is suitable for implanting same within a human body which permits controlled and convenient dispensing of fluid medicament to a desired somewhat remote location within the body. Propelling assemblies and blocking assemblies are provided and positioned so that they cooperate with each other along a medicament flow channel within the device in order to provide a controlled dispensing of a unit dose of medicament to the desired remote location. The medicament flow channel includes a blocking assembly at its downstream end.

Claims

1. An implantable, manually operable dispenser for a fluid medicament, comprising;

(a) a body member having reservoir means for storing a fluid medicament, said reservoir means having a flexible wall that expands and collapses as fluid medicament flows respectively into and out of the reservoir means;

(b) a supply port assembly on said body member, said supply port assembly being in fluid-passing communication with said reservoir means;

(c) a connecting channel within said body member, said connecting channel having a section thereof that is in fluid-passing communication with said reservoir means and another section thereof that is in fluid-passing communication with a delivery tube outlet from said body member;

(d) propelling means within said connecting channel for advancing fluid medicament in a downstream direction through said connecting channel toward said delivery tube outlet;

(e) one-way blocking means within said connecting channel for permitting, in cooperation with activation of said propelling means, controlled fluid flow therethrough toward said delivery tube outlet, said one-way blocking means also being for preventing fluid flow therethrough toward said delivery tube outlet when said propelling means is not activated; and

wherein said blocking means includes a diaphragm that is tensioned when there is no pressure differential thereacross and that sealingly engages a collar of the body member, and wherein said diaphragm has an aperture therethrough.

2. The implantable dispenser according to claim 1, further including another controlled-flow blocking means positioned within a segment of the connecting channel that is between said propelling means and said reservoir means.

3. The implantable dispenser according to claim 1, wherein a plurality of blocking means are provided so as to be both upstream and downstream of said propelling means.

4. The implantable dispenser according to claim 3, further including a plurality of said propelling means having blocking means both upstream and downstream thereof.

5. The implantable dispenser according to claim 1, further including three blocking means and two propelling means that are alternately located with respect to each other within the connecting channel.

6. The implantable dispenser according to claim 1, wherein the propelling means includes sealing means for blocking the flow of fluid therethrough when said propelling means is at its inwardly directed, depressed position and when said propelling means is at its outwardly directed, extended position.

8. The implantable dispenser according to claim 1, wherein the body member includes a plurality of said propelling means for metering and displacing substantially equal quantities of liquid medicament, and another blocking means is provided between said plurality of propelling means.

9. The implantable dispenser according to claim 1, wherein said propelling means includes a pushbutton having a stem extending into a chamber of the body member, and resilient means mounted to said stem for sealingly engaging and closing said chamber when said pushbutton is at its outwardly directed, extended position.

10. The implantable dispenser according to claim 9, wherein said propelling means further includes a resilient pad to which said pushbutton is mounted, said resilient pad providing means for biasing said propelling means to said sealing engagement and closing of said chamber.

11. The implantable dispenser according to claim 8, wherein the blocking means closest to said outlet from the body member is structured for opening at a pressure greater than pressure needed for outwardly moving the propelling means most closely spaced therefrom.

12. The implantable dispenser according to claim 1, wherein said supply port assembly includes one-way means for shutting off flow between said supply port assembly and said reservoir means.

13. The implantable dispenser according to claim 12, wherein said one-way means includes a resilient mushroom-shaped member mounted within a passageway space through said body member, said resilient mushroom-shaped member including an extending foot partially defining said reservoir means and including an extending cap opposite of said extending foot, said extending cap having a channel therethrough.

14. The implantable dispenser according to claim 13, wherein said supply port assembly further includes a needle stop plate movable toward and away from said extending cap of the mushroom-shaped member, and a domed pad covers said needle stop plate.

16. The implantable dispenser according to claim 8, wherein the propelling means that is most downstream includes resilient means mounting a pushbutton of the propelling means to said body member, said resilient means biasing said pushbutton in a depressed orientation, and wherein upstream propelling means includes resilient means mounting a pushbutton of the propelling means to said body member, said resilient means biasing said pushbutton in an outwardly extended orientation.

18. The implantable dispenser according to claim 1, wherein said propelling means includes plunger means for reciprocatingly opening and closing a chamber of the body member in communication with said connecting channel.

19. The implantable dispenser according to claim 16, wherein said downstream propelling means and said upstream propelling means are in fluid-passing communication through a segment of said connecting channel, whereby depression of said upstream propelling means outwardly extends said downstream propelling means.

7. An implantable, manually operable dispenser for a fluid medicament, comprising;

(a) a body member having reservoir means for storing a fluid medicament, said reservoir means having a flexible wall that expands and collapses as fluid medicament flows respectively into and out of the reservoir means;

(b) a supply port assembly on said body member, said supply port assembly being in fluid-passing communication with said reservoir means;

(c) a connecting channel within said body member, said connecting channel having a section thereof that is in fluid-passing communication with said reservoir means and another section thereof that is in fluid-passing communication with a delivery tube outlet from said body member;

(d) propelling means within said connecting channel for advancing fluid medicament in a downstream direction through said connecting channel toward said delivery tube outlet;

(e) one-way blocking means within said connecting channel for permitting, in cooperation with activation of said propelling means, controlled fluid flow therethrough toward said delivery tube outlet, said one-way blocking means also being for preventing fluid flow therethrough toward said delivery tube outlet when said propelling means is not activated, and said blocking means includes a diaphragm that is tensioned when there is no pressure differential thereacross and that sealingly engages a collar of the body member; and

wherein said propelling means includes plunger means for reciprocatingly opening and closing a chamber of the body member through which said plunger means is mounted.

15. An implantable, manually operable dispenser for a fluid medicament, comprising;

(a) a body member having reservoir means for storing a fluid medicament, said reservoir means having a flexible wall that expands and collapses as fluid medicament flows respectively into and out of the reservoir means;

(b) a supply port assembly on said body member, said supply port assembly being in fluid-passing communication with said reservoir means;

(c) a connecting channel within said body member, said connecting channel having a section thereof that is in fluid-passing communication with said reservoir means and another section thereof that is in fluid-passing communication with a delivery tube outlet from said body member;

(d) propelling means within said connecting channel for advancing fluid medicament in a downstream direction through said connecting channel toward said delivery tube outlet;

(e) one-way blocking means within said connecting channel for permitting, in cooperation with activation of said propelling means, controlled fluid flow therethrough toward said delivery tube outlet, said one-way blocking means also being for preventing fluid flow therethrough toward said delivery tube outlet when said propelling means is not activated;

(f) a plurality of blocking means are provided so as to be both upstream and downstream of said propelling means, wherein said blocking means downstream of the propelling means includes a diaphragm that is tensioned when there is no pressure differential thereacross and that sealingly engages a collar of the body member; and

(g) means are provided for transmitting fluid pressure within said reservoir means to said tensioned diaphragm and for sealingly engaging said tensioned diaphragm onto its said collar.

17. An implantable, manually operable dispenser for a fluid medicament, comprising;

(a) a body member having reservoir means for storing a fluid medicament, said reservoir means having a flexible wall that expands and collapses as fluid medicament flows respectively into and out of the reservoir means;

(b) a supply port assembly on said body member, said supply port assembly being in fluid-passing communication with said reservoir means;

(c) a connecting channel within said body member, said connecting channel having a section thereof that is in fluid-passing communication with said reservoir means and another section thereof that is in fluid-passing communication with a delivery tube outlet from said body member;

(d) propelling means within said connecting channel for advancing fluid medicament in a downstream direction through said connecting channel toward said delivery tube outlet;

(e) one-way blocking means within said connecting channel for permitting, in cooperation with activation of said propelling means, controlled fluid flow therethrough toward said delivery tube outlet, said one-way blocking means also being for preventing fluid flow therethrough toward said delivery tube outlet when said propelling means is not activated; and

(f) another controlled-flow blocking means positioned within a segment of the connecting channel that is between said propelling means and said reservoir means, wherein said blocking means between the propelling means and the reservoir means includes a diaphragm that is tensioned when there is no pressure differential thereacross and that sealingly engages a collar of the body member, and wherein said diaphragm has an aperture therethrough.