Apparatus and method for continuous non-invasive cardiovascular monitoring
First Claim
1. A method tor use in determining arterial blood pressure in a subject comprising the steps of:
- undertaking a calibration phase comprised of the steps of determining blood pressure and arterial wall displacement values of said subject occurring in response to corresponding initial conditions of blood flow, and ascertaining, in response to said determined values, the values of a plurality of coefficients, each of which is associated with a corresponding term in a pre-defined relationship that characterizes arterial blood pressure as a function of arterial wall displacement,undertaking a continuous monitoring phase comprised of the steps of measuring subsequently occurring actual arterial wall displacement values, generating a corresponding blood pressure value in response to said relationship and to at least one of each of said actual arterial displacement values, and repeating said calibration phase at the occurrence of any one of a plurality of pre-defined events or at pre-defined times.
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Accused Products
Abstract
Apparatus and related methods for continuous long-term non-invasive measurement of the pressure of a pulsatile fluid flowing through a flexible tube, particularly human arterial blood flow, is disclosed. Specifically, the apparatus provides a continuous calibrated pressure measurement by first undertaking a "calibration" phase comprised of determining the pressure at various pre-defined conditions of flow and, in reponse thereto, ascertaining the values of a plurality of coefficients each of which is associated with a corresponding term in a pre-defined function that characterizes fluid pressure in relation to pulsatile displacement of the wall of the tube; and second, undertaking a "continuous monitoring" phase comprised of determining each subsequently occurring pressure value as the pre-defined function of each corresponding pulsatile wall displacement value, and re-initiating the calibration phase at the expiration of pre-defined time intervals which adaptively change based upon current and prior results. Methods, which are particularly useful in conjunction with the disclosed apparatus, for ascertaining systolic and diastolic arterial blood pressure values are also disclosed.
102 Citations
57 Claims
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1. A method tor use in determining arterial blood pressure in a subject comprising the steps of:
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undertaking a calibration phase comprised of the steps of determining blood pressure and arterial wall displacement values of said subject occurring in response to corresponding initial conditions of blood flow, and ascertaining, in response to said determined values, the values of a plurality of coefficients, each of which is associated with a corresponding term in a pre-defined relationship that characterizes arterial blood pressure as a function of arterial wall displacement, undertaking a continuous monitoring phase comprised of the steps of measuring subsequently occurring actual arterial wall displacement values, generating a corresponding blood pressure value in response to said relationship and to at least one of each of said actual arterial displacement values, and repeating said calibration phase at the occurrence of any one of a plurality of pre-defined events or at pre-defined times. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
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34. Apparatus for determining arterial blood pressure in a subject comprising:
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means for undertaking a calibration phase comprising means for determining the blood pressure values occurring in response to corresponding initial conditions of blood flow, and means for ascertaining, in response to said determined blood pressure values, the values of a plurality of coefficients, each of which is associated with a corresponding term in a pre-defined relationship that characterizes arterial blood pressure as a function of arterial wall displacement, means for undertaking a monitoring phase comprising means for measuring subsequently occurring acutal arterial wall displacement values, means for generating a corresponding blood pressure value in response to said relationship and to at least one of each of said actual arterial displacement values, and means for repeating said calibration phase at the occurrence of any one of a plurality of pre-defined events or at pre-defined times. - View Dependent Claims (35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50)
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51. A method for use in determining arterial blood pressure in a subject, comprising the steps of:
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undertaking a calibration phase comprised of the steps of determining blood pressure values and values of a physiologic parameter of said subject related to blood pressure both values occurring in response to corresponding initial conditions of blood flow, and ascertaining, in response to said determined values, the values of a plurality of coefficients, each of which is associated with a corresponding term in a pre-defined relationship that characterizes arterial blood pressure as a function of said physiologic parameter; and undertaking a continuous monitoring phase comprised of the steps of measuring subsequently occurring actual values of said physiologic parameter, generating a corresponding blood pressure value in response to said relationship and to at least one of each of said actual physiologic parameter values, and repeating said calibration phase at the occurrence of any one of a plurality of pre-defined events or at pre-defined times. - View Dependent Claims (52, 53, 54, 55, 56, 57)
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Specification