Method of forming prosthetic devices
First Claim
1. A method of forming a prosthetic fabric device at least a portion of which is of a bioresorbable material whose surface properties favor fibroblast cell attachment and adhesion, and also encourage the infiltration of macrophages comprising the steps of dipping said device at a controlled rate into a solution of a bioresorbable, vasotropic effect inducing material, partial drying and inverting said device and redipping said device in said solution to form a bioresorbable coating on said device.
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Accused Products
Abstract
A sterile shaped prosthetic device, suitable for insertion into a mammalian body, is at least partly composed of a bioresorbable material that is digestible by macrophages, its surface properties favor the attachment and adhesion of fibroblast cells capable of producing collagen for organized connective tissues, and the material itself or its degradation products can induce in vivo the formation of new capillary vessels (termed a "vasotropic" effect herein). Preferred prosthetic devices have through passages, the interspatial dimensions which are sufficient to permit several layers of mammalian cells to form within each passage. The invading fibroblast cells commence formation of collagen leading to connective tissue while macrophages and extracellular enzymes degrade the material, and newly formed capillary vessels penetrate the prosthesis and provide blood containing oxygen and nutrients which further the formation of organized tissue around as well as within the prosthetic device.
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Citations
10 Claims
- 1. A method of forming a prosthetic fabric device at least a portion of which is of a bioresorbable material whose surface properties favor fibroblast cell attachment and adhesion, and also encourage the infiltration of macrophages comprising the steps of dipping said device at a controlled rate into a solution of a bioresorbable, vasotropic effect inducing material, partial drying and inverting said device and redipping said device in said solution to form a bioresorbable coating on said device.
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10. A method of forming a tubular vascular fabric prothesis at least a portion of which is of a bioresorbable material whose surface properties favor fibroblast cell attachment and adhesion, and also encourage the infiltration of macrophages comprising the steps of dipping said device at a controlled rate into a solution of synthetic bioresorbable, vasotropic effect inducing material partial drying inverting said device and redipping said device in said solution to form a bioresorbable coating on said device.
Specification