Adenosine in the treatment of supraventricular tachycardia

• US 4,673,563 A
• Filed: 04/08/1985
• Issued: 06/16/1987
• Est. Priority Date: 10/14/1980
• Status: Expired due to Term

• Current Assignee: The University of Virginia Patent Foundation
• Original Assignee: University of Virginia Patent Foundation (University of Virginia)
• Inventors: Belardinelli, Luiz, Rubio, Rafael, Berne, Robert M.
• Primary Examiner(s): NOT, DEFINED
• Application Number:
  US06/721,122
• Time in Patent Office: 799 Days
• Field of Search: 514/46, 424/9
• US Class Current: 424/9.1
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/46 8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
• CPC Class Codes: A61K 31/52 Purines, e.g. adenine

Abstract

A method of diagnosing and treating arrhythmias caused by re-entry in the A-V node by administering to a human or animal an effective amount of adenosine that restores normal sinus rhythm.

Claims

1. A method of treating supraventricular tachycardia caused by re-entry in the AV node, comprising the steps of:

(a) administering intravenously to a human afflicted with the tachycardia, 0.01-0.25 mg/kg of body weight of adenosine sufficient to restore normal rhythm.

2. The method of claim 1, wherein said tachycardia is Wolff-Parkinson-White syndrome.

3. The method of claim 1, wherein said tachycardia is reciprocating junctional tachycardia.

4. The method of claim 1, wherein said amount is 1-8 mg.

5. The method of claim 1, wherein said amount is about 0.06 mg/kg.

6. A method of diagnosing supraventricular tachycardia caused by re-entry in the AV node, comprising the steps of:

(a) administering intravenously to a human afflicated with the tachycardia 0.01-0.25 mg/kg of body weight of adenosine;

(b) monitoring the heart beat of said human for restoration of normal sinus rhythm; and

(c) determining the existence of the tachycardia.

7. The method of claim 6, wherein said tachycardia is Wolff-Parkinson-White syndrome.

8. The method of claim 6, wherein said tachycardia is reciprocating junctional tachycardia.

9. The method of claim 6, wherein said amount is 1-8 mg.

10. The method of claim 6, wherein said amount is about 0.06 mg/kg.