Method and apparatus for noninvasive determination of cardiac output

• US 4,676,253 A
• Filed: 07/18/1985
• Issued: 06/30/1987
• Est. Priority Date: 07/18/1985
• Status: Expired due to Fees

• Current Assignee: DOLL Medical Research Incorporated
• Original Assignee: DOLL Medical Research Incorporated
• Inventors: Newman, Warren, Persson, Alfred V.
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US06/756,805
• Time in Patent Office: 712 Days
• Field of Search: 128/691-694, 128/713, 128/663
• US Class Current: 600/506
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/0295 using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• CPC Class Codes: A61B 5/0535 Impedance plethysmography for measuring blood flow A61B5/0295
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives

Abstract

A determination of cardiac output of a living being is obtained noninvasively from measurements of heart rate and pulse timing points from a blood flow waveform in relation to the "R" line from a corresponding ECG signal. The blood flow waveform may be obtained indirectly, by differentiating the output of a plethysmograph or an instantaneous blood pressure sensor or by integrating the output of a doppler sensor, or indirectly from a magnetic flowmeter, for example. Heart rate and an "R" line trigger signal may be obtained from an electrocardiogram signal. Experimentally obtained heart rate and pulse timing data were compared with invasively measured cardiac output and were processed by regression analysis to yield an equation correlation of 0.73.

Claims

1. A method for determining the cardiac index of a living being, the method comprising:

sensing a series of electrocardiac first signals sensed at a first location on the skin surface of the living being adjacent to the heart for use as synchronizing and timing signals;

sensing a series of second signals sensed at a second location on the skin surface of the living being that are related to instantaneous blood flow;

processing the first signals to obtain an average heart rate value by averaging the durations between successive "R" lines of each electrocardiac wave;

processing the second signals to obtain a blood flow waveform signal corresponding to instantaneous blood flow at the second location;

measuring the time from each "R" line signal to a predetermined point on the corresponding blood flow waveform signal to determine at least one corresponding pulse delay timing value; and

processing the average heart rate value and the pulse delay timing value to obtain a final value representing the cardiac index of the living being.

2. The method according to claim 1 wherein the step of measuring the time from each "R" line signal to at least one predetermined point on the corresponding blood flow waveform signal comprises measuring the time from each "R" line signal to the peak of the systolic pulse of the corresponding blood flow waveform signal.

3. The method according to claim 1 wherein the step of measuring the time from each "R" line signal to at least one predetermined point on the corresponding blood flow waveform signal comprises measuring the time from each "R" line signal to the onset of the systolic pulse of the corresponding blood flow waveform signal.

4. The method according to claim 1 wherein the step of sensing a second signal at a second location on the skin surface of the living being comprises sensing the instantaneous impedance changes between two sites spaced apart along the length dimension of the limb to obtain an instantaneous blood volume signal.

5. The method according to claim 4 wherein the step of processing the second signal to obtain a blood flow waveform signal comprises differentiating the instantaneous blood volume signal.

6. The method according to claim 1 wherein the step of processing the average heart rate value and the pulse delay timing value to obtain a final value representing the cardiac index comprises

multiplying the average heart rate value by a first predetermined constant value to obtain a modified average heart rate value;

multiplying the pulse delay timing value by a predetermined constant value to obtain a modified pulse delay timing value; and

adding the modified average heart rate value to the modified pulse delay timing value.

7. The method according to claim 6 wherein the second predetermined constant value is a negative number.

8. The method according to claim 7 wherein the step of processing the average heart rate value and the pulse delay timing value further comprises adding a third predetermined constant value signal to the sum of the modified average heart rate and pulse delay timing values.

9. The method according to claim 1 further comprising the step of:

measuring the time from the onset to the peak of the systolic pulse portion of each blood flow waveform signal to obtain a systolic rise time value, modifying the final value processing step as follows;

processing the systolic rise time value, the average heart rate value and the pulse delay timing value to obtain said final value representing the cardiac index of the living being.

10. Apparatus for determining the cardiac index of a living being, the apparatus comprising:

means for sensing a series of electrocardiac first signals sensed on the skin surface of the living being;

means for sensing a series of second signals on the skin surface of the living being related to instantaneous blood flow;

means for processing the first signal to obtain an average heart rate value by averaging the times between successive "R" lines of each electrocardiac wave;

means for processing the second signals to obtain a blood flow waveform signal;

means for measuring the time from each "R" line signal to at least one predetermined point on the corresponding blood flow waveform signal to obtain at least one corresponding pulse delay timing value; and

means for processing the average heart rate value and the pulse delay timing value to obtain a final value representing the cardiac index of the living being.

11. The apparatus of claim 10 wherein the means for sensing said second signal comprises a plethysmograph.

12. The apparatus of claim 10 wherein the means for sensing said second signal comprises a doppler device.

13. The apparatus of claim 10 wherein the means for sensing said second signal comprises an electromagnetic flowmeter.

14. The apparatus of claim 10 wherein the means for sensing said second signal comprises a strain gage.