Automatic specimen analyzing system

• US 4,676,951 A
• Filed: 07/01/1985
• Issued: 06/30/1987
• Est. Priority Date: 07/01/1985
• Status: Expired due to Fees

• Current Assignee: Dade Microscan, Inc. (Siemens AG)
• Original Assignee: American Hospital Supply Corp. (Baxter International Inc.)
• Inventors: Armes, William P., Cherniski, Andrew M., Hathaway, James C., Hanaway, Richard W.
• Primary Examiner(s): NOT, DEFINED
• Application Number:
  US06/750,792
• Time in Patent Office: 729 Days
• Field of Search: 422/63-67, 422/100, 422/73, 422/102, 422/104, 422/72, 73/863.31, 73/863.32, 73/864.17, 73/864.18, 222/135, 222/137, 222/144, 222/144.5, 435/293, 435/300, 435/301, 356/246, 220/306, 220/352, 220/353, 436/809
• US Class Current: 422/65
• CPC Class Codes: G01N 2035/00356 Holding samples at elevated temperature (incubation)
• CPC Class Codes: G01N 2035/0425 Stacks, magazines or elevators for plates
• CPC Class Codes: G01N 2035/0443 for reagents
• CPC Class Codes: G01N 35/00 Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
• CPC Class Codes: G01N 35/028 having reaction cells in the form of microtitration plates
• CPC Class Codes: G01N 35/1002 Reagent dispensers
• CPC Class Codes: Y10S 436/809 Multifield plates or multicontainer arrays

Abstract

An automatic system for analyzing specimens which have been selectively treated. The specimens are arranged in a plurality of specimen trays with each tray containing a plurality of specimens. Tray towers support a plurality of specimen trays. A work station selectively moves the trays one at a time from the tower to selectively deliver reagent or analyze the specimen in the tray. A control system is adapted to sequentially actuate the work station to properly sequence the system so that the reagents are administered to the respective specimen and the specimen have been analyzed after a desired incubating period.

Claims

1. An automatic system for analyzing specimens which have been selectively treated as desired, said specimens being arranged in a plurality of specimens trays wherein each tray is adapted to contain a plurality of specimens, said system comprising:

means for supporting a plurality of specimen trays;

a work station associated with said tray supporting means for selectively treating or analyzing said specimens;

selectively operable tray moving means associated with said work station for removing a tray from said tray supporting means and for moving it to said work station and for reinserting it in said tray supporting mean;

a reagent delivery means associated with said work station selectively operable to administer a desired amount of at least one reagent to desired ones of said specimens in a tray;

analyzing means associated with said work station for determining at least one optical property of desired ones of said specimens in a tray;

said system including a plurality of said separate specimen tray supporting means and tray support moving means for selectively moving said tray supporting means so that a desired one of said tray supporting means is arranged in operative communication with said tray moving means and wherein said tray supporting means are arranged on said tray support moving means and wherein said tray support moving means surrounds said work station and said tray moving means; and

control means for sequentially actuating said tray moving means so that each tray is at least sequentially moved to said work station for administration of said reagent by said reagent delivery means;

returned to said tray supporting means;

moved to said work station after a desired time period for analysis by said analyzing means; and

return to said tray supporting means from which it can be removed for storage or disposal, and wherein said control means is operative to selectively actuate said tray support moving means to position said desired one of said tray supporting means.

2. A system as in claim 1 wherein said tray support moving means comprises a carousel arranged for rotation about said work station and wherein means are provided for releasably securing said plurality of said means for supporting specimen trays to said carousel.

3. A system as in claim 1 wherein said means for supporting a plurality of specimen trays, said work station, said selectively operable tray moving means, said reagent delivery means, and said analyzing means are arranged within an enclosing housing for providing a controlled environment and further including means for controlling the environment within said housing to provide a desired temperature and humidity adapted for proper incubation of the specimen.

4. A system as in claim 1 wherein said tray supporting means comprises tower means for supporting a plurality of trays in a substantially parallel overlapping relationship.

5. A system as in claim 4 wherein said tower means comprises a generally rectangular frame having a plurality of tray support shelves removably supported therein, said shelves being space apart a sufficient amount so that a tray can be placed therebetween and said shelves being arranged in a substantially parallel overlapping relationship in said frame.

6. A system as in claim 5 further comprising at least one specimen tray and wherein said tray comprises a container tray for holding said plurality of specimens and a cover member overlying said container tray to prevent loss or contamination of the specimens, said container tray being supportable in said tower means by one of said shelves and wherein said tower means further includes means for biasing said cover member against said container tray when they are positioned in said tower means.

7. A system as in claim 6 wherein said tower means includes means for capturing said cover member so that only the container tray is moved from said tower means to said work station by said tray moving means.

8. A system as in claim 7 wherein said tower means defines openings on one side through which an operator can insert said specimen tray into said tower means and defines corresponding openings on an opposing side thereof through which said container tray can be removed and moved to said work station and wherein selectively operable latch means are provided at said one side for preventing said specimen tray from being pushed out said one side by said tray moving means.

9. A system as in claim 8 wherein said tray moving means includes tine means insertable into said desired one of said tower means through a desired one of said openings in said opposing side for lifting said cover member off said container tray and for selectively capturing said container tray, said tine means being arranged for reciprocal movement between said tower means and said work station.

10. A system as in claim 9 wherein said tray moving means is supported by said work station and further includes means for selectivey moving said tine means reciprocally between said tower means and said work station in a first plane and a first direction in said plane.

11. A system as in claim 10 wherein said tray moving means further includes means for moving said tine means in a second plane normal to said first plane.

12. A system as in claim 11 wherein said reagent delivery means comprises a plurality of reagent supply containers remote from said work station and means for selectively dispensing said desired amount of a reagent from a corresponding one of said reagent supply containers.

13. A system as in claim 12 wherein said dispensing means further comprises dispensing head means at said work station for administering said reagents to said specimens, said dispensing head means being arranged for movement in said first plane in a second direction normal to said first direction, means for stepwise moving said dispensing head reciprocally in said first plane and second direction and conduit means communicating with said dispensing head and said selective dispensing means.

14. A system as in claim 13 wherein said selective dispensing means includes a dispensing station and wherein said reagent containers are arranged for movement past said dispensing station and wherein means are provided at said dispensing station for metering the amount of said reagent dispensed from said reagent container at said dispensing station.

15. A system as in claim 14 wherein said reagent containers comprise syringes and wherein said syringes are removably supported in a carousel arranged to rotate said syringes past said dispensing station and wherein means are provided for selectively moving said carousel to position a desired one of said syringes at said dispensing station.

16. A system as in claim 14 wherein said control system is adapted to coordinate the movement of a desired one of said reagent containers to said dispensing station and the amount of said reagent metered therefrom with the specimen arranged to receive said reagent.

17. A system as in claim 1 wherein said reagent delivery means comprises a plurality of reagent supply containers remote from said work station and means for selectively dispensing said desired amount of a reagent from a corresponding one of said reagent supply containers.

18. A system as in claim 17 wherein said selective dispensing means includes a dispensing station and wherein said reagent containers are arranged for movement past said dispensing station and wherein means are provided at said dispensing station for metering the amount of said reagent dispensed from said reagent container at said dispensing station.

19. A system as in claim 18 wherein said reagent containers comprise syringes and wherein said syringes are removably supported in a carousel arranged to rotate said syringes past said dispensing station and wherein means are provided for selectively moving said carousel to position a desired one of said syringes at said dispensing station.

20. A system as in claim 19 wherein said control system is adapted to coordinate the movement of a desired one of said reagent containers to said dispensing station and the amount of said reagent metered therefrom with the specimen arranged to receive said reagent.