Antimicrobial compositions

• US 4,677,143 A
• Filed: 11/27/1985
• Issued: 06/30/1987
• Est. Priority Date: 10/01/1984
• Status: Expired due to Term

• Current Assignee: Allegiance Corporation (Cardinal Health, Inc.)
• Original Assignee: Baxter Travenol Laboratories Incorporated
• Inventors: Laurin, Dean, Stupar, James
• Primary Examiner(s): NOT, DEFINED
• Assistant Examiner(s): Moore, M. L.
• Application Number:
  US06/802,555
• Time in Patent Office: 580 Days
• Field of Search: 523/122, 106/15.05, 106/16, 604/265
• US Class Current: 424/618
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/10 Macromolecular compounds
• CPC Class Codes: A01N 59/16 Heavy metals; Compounds thereof
• CPC Class Codes: A61L 2300/102 Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: C08K 3/015 Biocides macromolecular substances as carriers for biocide material A01N25/10
• CPC Class Codes: C08L 55/02 ABS [Acrylonitrile-Butadiene-Styrene] polymers

Abstract

Antimicrobial compositions finding particular utility for coating access systems, lead devices including shunts, cannulae, catheters, catheter adapters, wires and other solid or hollow tubular devices used for a variety of medical purposes is provided. The composition comprises a material selected from the group consisting of acrylonitrile-butadiene-styrene copolymers, polyvinyl chloride, mixtures thereof, polyesters, polyurethanes, styrene-block copolymers, natural and synthetic rubbers, polycarbonates, nylon and silicone rubber mixed with an oligodynamic material consisting essentially of compounds of physiological, antimicrobial metals.

Claims

1. An antimicrobial composition comprising:

30-99.85% by weight of a binder; and

0.15-70% by weight of an antimicrobial metal compound, said binder having a sufficiently low dielectric constant so as to allow said antimicrobial compound to form a chain-like structure to create an initial dose of antimicrobial action upon first use by allowing antimicrobial ions on a surface of said composition to dissove, said chain-like structure providing a pathway in said binder to allow interior antimicrobial ions in said composition to come to said surface of said composition to provide subsequent doses of antimicrobial action.