Cardiovascular prosthesis

• US 4,678,468 A
• Filed: 08/05/1985
• Issued: 07/07/1987
• Est. Priority Date: 08/07/1984
• Status: Expired due to Fees

• Current Assignee: UBE Industries Limited (UBE Corporation)
• Original Assignee: Bio-Medical Company Limited
• Inventors: Hiroyoshi, Toshiki
• Primary Examiner(s): McNeill, Gregory E.
• Application Number:
  US06/762,168
• Time in Patent Office: 701 Days
• Field of Search: 623/1
• US Class Current: 623/1.49
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: C08L 101/00 Compositions of unspecified macromolecular compounds
• CPC Class Codes: C08L 83/04 Polysiloxanes

Abstract

In a cardiovascular prosthesis, at least a part of blood contact surface of the prosthesis is formed by polymer composition comprising water soluble polymer such as heparin and crosslinked polysiloxane, at least a part of the water soluble polymer being entangled or intertwisted into polysiloxane networks.

Claims

1. A cardiovascular prosthesis, wherein at least a part of its blood contact surface is formed by a polymer composition comprising a water soluble polymer and a crosslinked polysiloxane, at least a part of said water soluble polymer being entangled or intertwisted into polysiloxane networks.

2. A cardiovascular prosthesis according to claim 1, wherein said water soluble polymer includes heparin as an essential ingredient and at least a part of heparin as well as the other water soluble polymer component or components is entangled or intertwisted into said polysiloxane networks.

3. A cardiovascular prosthesis according to claim 2, wherein said water soluble polymer further includes polyvinyl alcohol.

4. A cardiovascular prosthesis according to claim 1, wherein said water soluble polymer comprises at least one selected from the group consisting of polyethylene glycol, polypropylene glycol, ethylene oxide-propylene oxide copolymer, polyvinyl pyrrolidone, soluble collagen, gelatin, polyacrylic acid, polymethacrylic acid, polyhydroxy-ethyl methacrylic acid, polyhydroxy ethylacrylic acid, polyacrylamide, polymethacrylamide, 2-acrylamide-2-methylpropane sulfonic acid, soluble starch, methyl cellulose, polysaccharide hyaluronic acid, chondroitin sulfate, oxidized starch and dialdehyde starch.

5. A method of producing a cardiovascular prosthesis, wherein a base body of said prosthesis is treated with a solution comprising a water soluble polymer and a silico-component which has a capability of inducing polymerization to crosslinked polysiloxane.

6. A method of producing a cardiovascular prosthesis according to claim 5, wherein said water soluble polymer includes heparin as an essential ingredient.

7. A method of producing a cardiovascular prosthesis according to claim 6, wherein said water soluble polymer further includes polyvinyl alcohol.

8. A method of producing a cardiovascular prosthesis according to claim 5, wherein said silico-component is one of the group formulated as:

space="preserve" listing-type="equation">R.sub.n --Si--R'"'"'.sub.n-n

where R is a hydrocarbon radical, R'"'"' is one of alkoxy, acyloxy, halogen and amino radical, and n is 0, 1 or 2.

9. A method of producing a cardiovascular prosthesis according to claim 5, wherein said silico-component is one of the group formulated as:

space="preserve" listing-type="equation">R.sub.n R'"'"'.sub.3-n Si--O--SiR.sub.m R".sub.3-m

where n and m are selected from 1, 2 and 3, respectively, n+m=0, 1, 2, 3 or 4, R is a hydrocarbon radical, and R'"'"' and R" are selected from the group capable of converting to a functional group inducing polymerization by activation.

10. A method of producing a cardiovascular prosthesis according to claim 5, wherein said silico-component is one of silane coupling agents for room temperature vulcanization.

11. A method of producing a cardiovascular prosthesis according to claim 5, wherein said water soluble polymer is at least one selected from the group consisting of polyethylene glycol, polypropylene glycol, ethylene oxide-propyleneoxide copolymer, polyvinyl pyrrolidone, soluble collagen, gelatin, polyacrylic acid, polymethacrylic acid, polyhydroxy ethyl methacrylic acid, polyhydroxy ethyl acrylic acid, polyacrylamide, polymethacrylamide, 2-acrylamide-2-methyl-propane sulfonic acid, soluble starch, methyl cellulose, polysaccharide, hyaluronic acid, chondroitin sulfate, oxidized starch or dialdehyde starch.