Method of reducing soft tissue swelling and pain

• US 4,678,668 A
• Filed: 10/28/1985
• Issued: 07/07/1987
• Est. Priority Date: 10/28/1985
• Status: Expired due to Fees

• Current Assignee: MD Associates A Partnership Composed of James Mckay and Robert L Darras
• Original Assignee: MD Associates
• Inventors: Darras, Robert L.
• Primary Examiner(s): Friedman, Stanley J.
• Application Number:
  US06/792,001
• Time in Patent Office: 617 Days
• Field of Search: 424/94
• US Class Current: 424/94.1
• CPC Class Codes: A61K 38/4873 Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: C12Y 304/22002 Papain (3.4.22.2)

Abstract

Disclosed is a composition and a method for reducing soft tissue swelling and pain. A composition comprising of proteolytic enzyme and a transfer vehicle is topically applied to the injured bodily area. Relief is rapid.

Claims

1. A method for reducing soft tissue swelling and pain of animals comprising administering topically to the animal a composition comprising from 10 to 100 units of a proteolytic enzyme selected from the group consisting of papain, trypsin, chymotrypsin, hyalurionidase or mixtures thereof dissolved in a transfer vehicle in an amount sufficient to transport the proteolytic enzyme through the soft tissue of the animal.

2. A method according to claim 1 wherein the proteolytic enzyme is papain.

5. A method according to claim 1 wherein from 10 to 100 units of proteolytic enzyme per 50 ml of liquid transfer vehicle are administered.

3. A method for reducing soft tissue swelling and pain of animals comprising administering topically to the animal 10 to 100 units of a composition comprising a proteolytic enzyme selected from the group consisting of papain, trypsin, chymotrypsin, hyalurionidase or mixtures thereof dissolved in a transfer vehicle in an amount sufficient to transport the proteolytic enzyme through the soft tissue of the animal, wherein the transfer vehicle is selected from the group consisting of glycerin, alcohol, water and hydroalcoholic based topically administerable pharmaceutical carriers.

4. A method according to claim 3 wherein the transfer vehicle is a mixture consisting essentially of alcohol, isopropyl alcohol, purified water, propylene glycol, and laureth-4.

6. A method for reducing soft tissue swelling and pain in animals consisting essentially of topically administering to the soft tissue of the animals a solution consisting essentially of 18 units of papain per 50 ml of a mixture consisting essentially of alcohol, isopropyl, alcohol, purified water, propylene glycol, and laureth-4.