Quaternary 3,4-dihydro-isoquinolinium salts
First Claim
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1. A pharmaceutical composition containing an amount effective to prevent or treat a thromboembolic disease of a 3,4-dihydroisoquinolinium salt of formula I ##STR5## wherein R1 and R2 are each independently hydrogen, C1 -C3 alkyl or C1 -C3 alkoxy;
- R3 is a C7 -C9 aralkyl, the phenyl nucleus of which can be mono-, di- or trisubstituted by halogen, C1 -C3 alkyl or C1 -C3 alkoxy; and
X represents the anion of a pharamaceutically acceptable inorganic or organic acid, together with one or more pharmaceutically acceptable carriers or diluents.
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Abstract
This invention relates to a compound of formula (I) ##STR1## wherein R1 and R2 are each independently hydrogen, C1 -C3 alkyl or C1 -C3 alkoxy; and R3 is a C7 -C9 aralkyl, the phenyl nucleus of which can be mono-, di-, or trisubstituted by halogen, C1 -C3 alkyl or C1 -C3 alkoxy, and nontoxic, pharmaceutically acceptable salts thereof. The compounds have useful antithrombic properties.
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15 Claims
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1. A pharmaceutical composition containing an amount effective to prevent or treat a thromboembolic disease of a 3,4-dihydroisoquinolinium salt of formula I ##STR5## wherein R1 and R2 are each independently hydrogen, C1 -C3 alkyl or C1 -C3 alkoxy;
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R3 is a C7 -C9 aralkyl, the phenyl nucleus of which can be mono-, di- or trisubstituted by halogen, C1 -C3 alkyl or C1 -C3 alkoxy; and X represents the anion of a pharamaceutically acceptable inorganic or organic acid, together with one or more pharmaceutically acceptable carriers or diluents. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 12, 14)
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9. A pharmaceutical composition comprising from about 125 mg to about 500 mg of a 3,4-dihydroisoquinolinium salt of formula I:
- ##STR6## wherein R1 and R2 are each independently hydrogen, C1 -C3 alkyl or C1 -C3 alkoxy;
R3 is a C7 -C9 aralkyl, the phenyl nucleus of which can be mono-, di- or trisubstituted by halogen, C1 -C3 alkyl or C1 -C3 alkoxy, and X represents the anion of a pharmaceutically acceptable inorganic or organic acid, together with one or more carriers or diluents. - View Dependent Claims (10, 11, 13, 15)
- ##STR6## wherein R1 and R2 are each independently hydrogen, C1 -C3 alkyl or C1 -C3 alkoxy;
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Current AssigneeDr. Karl Thomae GmbH (C.H. Boehringer Sohn AG & Co. KG)
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Original AssigneeDr. Karl Thomae GmbH (C.H. Boehringer Sohn AG & Co. KG)
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InventorsNarr, Benthold, Muller, Erich, Haarmann, Walter, Ballhause, Helmut, Nickl, Josef
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Primary Examiner(s)WADDELL, FREDERICK
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Application NumberUS06/706,579Time in Patent Office859 DaysField of Search514/307US Class Current514/307CPC Class CodesA61P 7/02 Antithrombotic agents; Anti...C07D 217/02 with only hydrogen atoms or...C07D 217/04 with hydrocarbon or substit...
