Drug administering apparatus

• US 4,681,582 A
• Filed: 06/11/1985
• Issued: 07/21/1987
• Est. Priority Date: 06/13/1984
• Status: Expired due to Fees

• Current Assignee: Terumo Kabushiki Kaisha (Terumo Corporation)
• Original Assignee: Terumo Kabushiki Kaisha (Terumo Corporation)
• Inventors: Yamamoto, Yuichi
• Primary Examiner(s): YASKO JR, JOHN D
• Application Number:
  US06/743,412
• Time in Patent Office: 770 Days
• Field of Search: 604/890, 604/891, 604/892, 604/83, 604/84
• US Class Current: 424/450
• CPC Class Codes: A61K 9/127 Liposomes
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

A drug administering apparatus includes a container with body fluid inlet and outlet ports which communicate with each other, and a liposome agent entrapping a drug therein. An insoluble substance is fixed inside the container and has the liposome agent such that the liposome agent can be brought into contact with the body fluid flowing in the container. The drug entrapped in the liposome is released into the body fluid flowing in the container.

Claims

1. A drug administering apparatus comprising:

a container with body fluid inlet and outlet ports which communicate with each other;

a liposome agent entrapping a drug therein; and

an insoluble substance fixed inside said container and having said liposome agent such that said liposome agent can be brought into contact with the body fluid flowing in said container;

said insoluble substance comprising a polymeric substance having a hydrophilic group and having been crosslinked to have a three-dimensional network structure;

said liposome agent being held between lattices of said network structure;

whereby said drug entrapped in said liposome agent is released into the body fluid flowing in said container.

2. An apparatus according to claim 1, wherein the polymeric substance is crosslinked by irradiation with gamma-rays.

3. An apparatus according to claim 2, wherein the polymeric substance is a hydrogel.

4. An apparatus according to claim 3, wherein the polymeric substance has a biocompatibility.

5. An apparatus according to claim 4, wherein the polymeric substance is a member selected from the group consisting of polyacrylamide, polyvinyl alcohol, gelatin, polyvinyl pyrrolidone, poly-(2-hydroxyethylmethacrylate), polymethacrylate, poly-(N,N-dimethylaminoethylmethacrylate), polyethylene oxide, polysaccharide, sodium alginate, collagen, and fibrin.

6. An apparatus according to claim 1, wherein the liposome is constituted by a phospholipid.

7. An apparatus according to claim 1, wherein the polymeric substance is fixed on an insoluble support.

8. An apparatus according to claim 7, wherein the insoluble support comprises granules filled in the container.

9. An apparatus according to claim 8, wherein the granules have an average size of 0.1 to 5 mm.

10. An apparatus according to claim 7, wherein the insoluble support comprises hollow fibers packed in the container.

11. An apparatus according to claim 10, wherein the polymeric substance is fixed on an inner surface of each of the hollow fibers.

17. An apparatus according to claim 1, wherein said polymeric substance is crosslinked at a crosslinking degree of 6 to 80%.

12. A drug administering apparatus comprising:

a container with body fluid inlet and outlet ports which communicate with each other;

a liposome agent entrapping a drug therein; and

an insoluble substance fixed inside said container and having said liposome agent such that said liposome agent can be brought into contact with the body fluid flowing in said container;

said insoluble substance being crosslinked to have a three-dimensional network structure;

said insoluble substance being obtained by irradiating a mixture of a hydrogel comprising a polymeric substance and said liposome agent with gamma rays, thereby providing said network structure and allowing said liposome agent to be held between lattices of said network structure.

13. An apparatus according to claim 12, wherein the polymeric substance is a hydrogel.

14. An apparatus according to claim 12, wherein the liposome is constituted by a phospholipid.

15. An apparatus according to claim 12, wherein the polymeric substance is fixed on an insoluble support.

16. An apparatus according to claim 12, wherein said polymeric substance is crosslinked at a crosslinking degree of 6 to 80%.