Biomaterial

• US 4,681,588 A
• Filed: 06/17/1985
• Issued: 07/21/1987
• Est. Priority Date: 10/20/1983
• Status: Expired due to Term

• Current Assignee: Wilkracht Pty Limited
• Original Assignee: Bio Nova NEO Technics Pty Limited of Victoria
• Inventors: Ketharanathan, Vettivetpillai
• Primary Examiner(s): Apley, Richard J.
• Assistant Examiner(s): Cannon, Alan W.
• Application Number:
  US06/760,745
• Time in Patent Office: 764 Days
• Field of Search: 424/95, 8/94.11, 623/1, 623/2, 623/11, 623/15, 623/66, 128/334 R, 128/1 R
• US Class Current: 623/23.72
• CPC Class Codes: A61K 35/42 Respiratory system, e.g. lungs, bronchi or lung cells
• CPC Class Codes: A61L 15/40 containing ingredients of undetermined constitution or reaction products thereof , e.g. plant or animal extracts
• CPC Class Codes: A61L 2430/40 Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking
• CPC Class Codes: A61L 27/36 containing ingredients of undetermined constitution or reaction products thereof , e.g. transplant tissue, natural bone, extracellular matrix isolated natural compounds, e.g. collagen A61L27/24
• CPC Class Codes: A61L 27/3604 characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
• CPC Class Codes: A61L 27/3687 characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
• CPC Class Codes: A61L 27/60 Materials for use in artificial skin

Abstract

Material for use in a biological environment is produced by subjecting a sheet of parietal pleura to glutaraldehyde tanning. The pleura is stretched and cleansed of excessive tissue to result in a membrane of substantially uniform thickness prior to tanning.

The material produced by the invention may be used as a surgical graft material, in which case the visceral surface of the pleura may provide a blood contacting surface. The material may also be used as a surgical dressing.

The pleura may be obtained from various animal species but will commonly be bovine pleura.

Claims

1. A biomaterial comprising a sheet of animal parietal pleura which has been subjected to glutaraldehyde tanning.

2. A material as claimed in claim 1 wherein the pleura is bovine pleura.

3. A method of producing the biomaterial of claim 1 comprising subjecting a sheet of animal parietal pleura to glutaraldehyde and tanning said sheet to provide a sheet of glutaraldehyde tanned animal parietal pleura.

4. A method as claimed in claim 3 wherein the pleura is bovine pleura.

5. A method as claimed in claim 3 wherein the pleura is stretched and cleansed of excessive tissue to result in a membrane of substantially uniform thickness prior to tanning.

6. A method as claimed in claim 3 wherein the pleura is tanned in a solution of buffered glutaraldehyde of between 2-8 pH having a concentration of 0.5%-5% by weight and is immersed in the solution for a period within the range 15 minutes to 72 hours.

7. A method of treating a living human patient comprising applying a sheet of animal parietal pleura of claim 1 which has been subjected to glutaraldehyde tanning as a surgical graft or as a dressing to the patient.

8. A method of treating a living human patient comprising applying to the patient the biomaterial produced by the method claimed in claim 3 as a surgical graft or as a dressing.

9. A method as claimed in claim 7, comprising positioning the visceral surface of the pleura to provide a blood contacting surface.

10. The biomaterial as claimed in claim 1 wherein the visceral surface of the pleura provides a blood contacting surface.

11. A shelf storable surgical graft for a living human patient adapted to support epithelial or endothelial growth composed of the biomaterial of claim 1.

12. A shelf storable surgical dressing for a living human patient adapted to support epithelial or endothelial growth composed of the biomaterial of claim 1.