Fiber optic probe for quantification of colorimetric reactions
First Claim
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1. An optical probe for colorimetric measurement, comprising:
- (a) an optical fiber, having an outer diameter and having light input and output ends for accepting the mounting of optical couplers to enable the transmission of light through said optical fiber, said optical fiber being doubled and having a sharp, 180°
bend at a point along its length so as to form a tip, the bend radius of said sharp 180°
bend being approximately equal to or less than the outer diameter of said optical fiber, said optical fiber having a small slice extracted from it at a point along its length spaced away from the tip so as to separate said optical fiber into two sections, each section having a face, the respective face of one section linearly displaced from the face of the other section, said displacement of said faces forming an optical gap;
(b) a tip support coating, said tip support coating covering the tip and further extending back along and covering the doubled length of said optical fiber for a distance beyond the optical gap, said tip support coating having a sample chamber which opens on the surface of said tip support coating and which extends into the interior of said tip support coating so as to expose the faces of said optical fiber at the optical gap;
(c) a colorimetric substance, said colorimetric substance filling the sample chamber, said colorimetric substance being permeable to a chemical of which properties are to be colorimetrically measured; and
(d) a semipermeable membrane, said semipermeable membrane being applied to the surface of said tip support coating so as to cover the opening of the sample chamber.
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Abstract
A fiber optical probe for colorimetric measurement of chemical properties suitable for the insertion into living tissue. A chemical to be colorimetrically measured is introduced into a sample chamber on the side of the probe near the probe tip. A colorimetric substance contained in the sample chamber changes colors in response to chemical properties of the chemical to be colorimetrically measured, thereby changing the amount of light transmitted through the sample chamber by the optical fibers.
254 Citations
17 Claims
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1. An optical probe for colorimetric measurement, comprising:
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(a) an optical fiber, having an outer diameter and having light input and output ends for accepting the mounting of optical couplers to enable the transmission of light through said optical fiber, said optical fiber being doubled and having a sharp, 180°
bend at a point along its length so as to form a tip, the bend radius of said sharp 180°
bend being approximately equal to or less than the outer diameter of said optical fiber, said optical fiber having a small slice extracted from it at a point along its length spaced away from the tip so as to separate said optical fiber into two sections, each section having a face, the respective face of one section linearly displaced from the face of the other section, said displacement of said faces forming an optical gap;(b) a tip support coating, said tip support coating covering the tip and further extending back along and covering the doubled length of said optical fiber for a distance beyond the optical gap, said tip support coating having a sample chamber which opens on the surface of said tip support coating and which extends into the interior of said tip support coating so as to expose the faces of said optical fiber at the optical gap; (c) a colorimetric substance, said colorimetric substance filling the sample chamber, said colorimetric substance being permeable to a chemical of which properties are to be colorimetrically measured; and (d) a semipermeable membrane, said semipermeable membrane being applied to the surface of said tip support coating so as to cover the opening of the sample chamber. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. An optical probe for colorimetric measurement, comprising:
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(a) a first optical fiber having a distal end prepared to accept an optical coupler and a proximate end having a face, said first optical fiber having a 180°
bend near its proximate end to form a tip, with bending radius being less than or equal to the diameter of said first optical fiber;(b) a second optical fiber having a distal end prepared to accept an optical coupler and a proximate end having a face, said second optical fiber being placed closely to and running parallel to said first optical fiber so that the proximate end face of said first optical fiber confronts the proximate end face of said second optical fiber to form an optical gap; (c) a flexible protective sheath surrounding said optical fibers, the respective proximate ends of said optical fibers protruding from the proximate end of said flexible protective sheath so as to leave the tip and the optical gap exposed, the distal ends of said optical fibers protruding from the distal end of said flexible protective sheath; (d) a rigid tip support coating covering that part of the proximate ends of said optical fibers exposed by said protective sheath and further extending inside and filling the interior of said protective sheath near the proximate end of said protective sheath, said tip support coating having a sample chamber opening on the surface of said tip support coating and extending inward into said tip support coating and the optical gap so as to expose the proximate end faces of said optical fibers; (e) a colorimetric substance filling said sample chamber, said colorimetric substance comprised of glass fragments with a dye bound thereto, the fragments being mixed with water to form a slurry; and (f) a semipermeable membrane applied to the surface of said tip support coating so as to cover the opening of the sample chamber, said semipermeable membrane extending back along said optical probe so as to cover a portion of said protective sheath, said semipermeable membrane being chosen so as to allow the flow of a selected chemical to be colorimetrically measured while prohibiting the flow of other chemicals.
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11. An optical probe for colorimetric measurement, comprising:
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(a) a first optical fiber having a distal end for engagement to an optical coupler and a proximate end having a cross-sectional surface, said first optical fiber having a substantially 180°
bend near its proximate end forming a tip;(b) a second optical fiber having a distal end for engagement to an optical coupler and a proximate end having a cross-sectional surface, said second optical fiber aligned substantially parallel to said first optical fiber such that the proximate cross-sectional surface of said first optical fiber faces the proximate cross-sectional surface of said second optical fiber forming an optical gap, said first optical fiber and said second optical fiber having outer diameters, the shortest distance between the part of the first optical fiber on one side of said bend and the part of the first optical fiber on the opposite side of the bend being less than or approximately equal to the outer diameter of said first optical fiber; (c) a tip support coating, said tip support coating covering the tip of said first optical fiber; (d) a semipermable membrane, said semipermeable membrane covering the opening of said optical gap to form a sample chamber. - View Dependent Claims (12, 13, 14, 15, 16, 17)
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Specification