Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures

• US 4,684,479 A
• Filed: 08/14/1985
• Issued: 08/04/1987
• Est. Priority Date: 08/14/1985
• Status: Expired due to Term

• Current Assignee: Cavitation-Control Technology Incorporated
• Original Assignee: Joseph S D'Arrigo
• Inventors: D'Arrigo, Joseph S.
• Primary Examiner(s): Terapane, John F.
• Assistant Examiner(s): Kilby, Catherine S.
• Application Number:
  US06/765,917
• Time in Patent Office: 720 Days
• Field of Search: 252/307, 252/356, 252/61, 252/DIG. 1, 514/945, 128/697
• US Class Current: 516/18
• CPC Class Codes: A61K 49/226 Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
• CPC Class Codes: C02F 1/24 by flotation C02F1/465 takes precedence
• CPC Class Codes: C09K 23/017 Mixtures of compounds
• CPC Class Codes: Y10S 516/06 Protein or carboxylic compound containing

Abstract

Surfactant mixtures for the production of stable gas-in-liquid emulsions are provided comprising:

(a) a member selected from the group consisting of glycerol monoesters of saturated carboxylic acids containing from about 10 to about 18 carbon atoms and aliphatic alcohols containing from about 10 to about 18 carbon atoms;

(b) a sterol-aromatic acid ester;

(c) a member selected from the group consisting of sterols, terpenes, bile acids and alkali metal salts of bile acids;

(d) a member selected from the group consisting of sterol esters of aliphatic acids containing from 1 to about 18 carbon atoms; sterol esters of sugar acids; esters of sugar acids and aliphatic alcohols containing from about 10 to about 18 carbon atoms; esters of sugars and aliphatic acids containing from about 10 to about 18 carbon atoms; sugar acids; saponins; and sapogenins; and

(e) a member selected from the group consisting of glycerol, glycerol di- or triesters of aliphatic acids containing from about 10 to about 18 carbon atoms and aliphatic alcohols containing from about 10 to about 18 carbon atoms;

said components being present in said mixture in a weight ratio a:b:c:d:e of 2-4:0.5-1.5:0.5-1.5:0-1.5:0-1.5.

Processes are also provided for forming stable gas-in-liquid emulsions from said surfactant mixtures.

Claims

1. A surfactant mixture for the production of stable gas-in-liquid emulsions comprising:

(a) a member selected from the group consisting of glycerol monoesters of saturated carboxylic acids containing from about 10 to about 18 carbon atoms and aliphatic acohols containing from about 10 to about 18 carbon atoms;

(b) a sterol-aromatic acid ester;

(c) a member selected from the group consisting of sterols, terpenes, bile acids and alkali metal salts of bile acids;

(d) a member selected from the group consisting of sterol esters of aliphatic acids containing from 1 to about 18 carbon atoms;

sterol esters of sugar acids;

esters of sugar acids and aliphatic alcohols containing from about 10 to about 18 carbon atoms;

esters of sugars and aliphatic acids containing from about 10 to about 18 carbon atoms;

sugar acids;

saponins; and

sapogenins; and

(e) a member selected from the group consisting of glycerol, glycerol di- or triesters of aliphatic acids containing from about 10 to about 18 carbon atoms and aliphatic alcohols containing from about 10 to about 18 carbon atoms;

said components being present in said mixture in a weight ratio a;

b;

c;

d;

e of 2-4;

0.5-1.5;

0.5-1.5;

0-1.5;

0-1.5.

2. A surfactant mixture for the production of stable gas-in-liquid emulsions as defined in claim 1 wherein the weight ratio a:

b;

c;

d;

e ranges from 2-4;

0.5-1.5;

0.5-1.5;

0.5-1.5;

0-1.5.

3. A surfactant mixture as defined in claim 1 wherein the weight ratio a:

b;

c;

d;

e ranges from 2-4;

1;

1;

1;

1.

4. A surfactant mixture as defined in claim 1 consisting essentially of glycerol monolaurate, cholesterol benzoate, cholesterol, cholesterol acetate and glycerol tripalmitate in a weight ratio of 2-4:

1;

1;

1;

1.

5. A process for the preparation of stable gas microbubbles in aqueous or oil-based media comprising:

forming at least a substantially saturated solution of a surfactant mixture comprising;

(a) a member selected from the group consisting of glycerol monoesters of saturated carboxylic acids containing from about 10 to about 18 carbon atoms and aliphatic alcohols containing from about 10 to about 18 carbon atoms;

(b) a sterol-aromatic acid ester;

(c) a member selected from the group consisting of sterols, terpenes, bile acids and alkali metal salts of bile acids;

(d) a member selected from the group consisting of sterol esters of aliphatic acids containing from 1 to about 18 carbon atoms;

sterol esters of sugar acids;

esters of sugar acids and aliphatic alcohols containing from about 10 to about 18 carbon atoms;

esters of sugars and aliphatic acids containing from about 10 to about 18 carbon atoms;

sugar acids;

saponins; and

sapogenins; and

(e) A member selected from the group consisting of glycerol, glycerol di- or triesters of aliphatic acids containing from about 10 to about 18 carbon atoms and aliphatic alcohols containing from about 10 to about 18 carbon atoms;

said components being present in said mixture in a weight ratio a;

b;

c;

d;

e of 2-4;

0.5-1.5;

0.5-1.5;

0-1.5;

0-1.5;

in an aqueous or oil-based medium;

shaking said substantially saturated solution of the surfactant mixture for from about 2 to about 10 seconds in the gaseous atmosphere at room temperature, thereby forming a concentrated gas-in-liquid emulsion.

6. Process as defined in claim 5 wherein the substantially saturated solution is formed in an aqueous medium.

7. Process as defined in claim 5 wherein the substantially saturated solution is formed in an oil-based medium.

8. Process as defined in claim 5 wherein the substantially saturated solution is formed by admixing from about 0.02 to about 0.4 gm of said surfactant mixture with 100 cc. of an aqueous or oil-based medium.

9. A process as defined in claim 5 wherein said components are present in said surfactant mixture in the weight ratio a:

b;

c;

d;

e of 2-4;

0.5-1.5;

0.5-1.5;

0.5-1.5;

0-1.5.

10. A process as defined in claim 5 wherein said components are present in said surfactant mixture in the weight ratio a:

b;

c;

d;

e of 2-4;

1;

1;

1;

1.

11. A stable gas-in-liquid emulsion obtained by the process of claim 5.

12. A stable gas-in-liquid emulsion obtained by the process of claim 6.

13. A stable gas-in-liquid emulsion obtained by the process of claim 7.