Local delivery of chemotherapeutic agents for the treatment of periodontal disease
First Claim
Patent Images
1. A method for local delivery of chemotherapeutic agents to localized sites in the mouth for treatment of periodontal disease, comprising the steps of:
- (a) displacing gingival tissue away from the surface of the root portion of a tooth so as to form a vacuous cavity between the tooth and the tissue within a peridontal pocket;
(b) insertion of biodegradable, time-release microshapes encapsulating chemotherapeutic agents, into the vacuous cavity between the tooth and the tissue within the periodontal pocket; and
(c) allowing the displaced gingival tissue to return substantially to its orginial position for retention of the biodegradable, time-release microspheres in the periodontal pocket whereby the biodegradable, time-release microspheres will begin to degrade and release the chemotherapeutic agents at a localized site.
0 Assignments
0 Petitions
Accused Products
Abstract
A method for local delivery of chemotherapeutic agent (12) to a localized site in the mouth is disclosed. The method of delivery includes displacement or reflection of gingival tissues (20) from the tooth, in the area to be treated, to facilitate access to the periodontal lesion (16). A biodegradable, time-release microsphere (10) capsulating the chemotherapeutic agent is next positioned in the lesion (16). Accordingly, localized delivery of chemotherapeutic agent (12) continuously over a predetermined period of time is provided.
146 Citations
7 Claims
-
1. A method for local delivery of chemotherapeutic agents to localized sites in the mouth for treatment of periodontal disease, comprising the steps of:
-
(a) displacing gingival tissue away from the surface of the root portion of a tooth so as to form a vacuous cavity between the tooth and the tissue within a peridontal pocket; (b) insertion of biodegradable, time-release microshapes encapsulating chemotherapeutic agents, into the vacuous cavity between the tooth and the tissue within the periodontal pocket; and (c) allowing the displaced gingival tissue to return substantially to its orginial position for retention of the biodegradable, time-release microspheres in the periodontal pocket whereby the biodegradable, time-release microspheres will begin to degrade and release the chemotherapeutic agents at a localized site. - View Dependent Claims (2, 3, 4)
-
-
5. a method for local delivery of chemotherapeutic agents to localized sites in the mouth for the treatment of periodontal disease, comprising the steps of:
-
(a) displacing gingival tissue away from the surface of the root portion of a tooth so as to form a vacuous cavity between the tooth and the tissue within a periodontal pocket (b) adhesively positioning a biodegradable matrix including a chemotherpeutic agent thereon, subgingivally on the surface of the root portion of the tooth proximate the vacuous cavity formed between the tooth and the tissue within the periodontal pocket and (c) returning the displaced gingival tissue to substantially its original position, the gingival tissue thereby assisting in retention of the chemotherapeutic agent in the periodontal pocket. - View Dependent Claims (6, 7)
-
Specification