Pharmaceutical delivery system

• US 4,687,660 A
• Filed: 08/15/1984
• Issued: 08/18/1987
• Est. Priority Date: 08/16/1983
• Status: Expired

• Current Assignee: Bend Research Inc. (Lonza Group AG)
• Original Assignee: Burroughs Wellcome and Co.
• Inventors: Baker, Richard W., Brooke, James W.
• Primary Examiner(s): GRIFFIN, RONALD
• Application Number:
  US06/640,951
• Time in Patent Office: 1,098 Days
• Field of Search: 424/19, 424/22, 424/32, 424/35, 424/15, 424/33, 604/890, 604/892
• US Class Current: 424/465
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61K 9/2826 Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
• CPC Class Codes: A61K 9/2853 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
• CPC Class Codes: A61K 9/2866 Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Abstract

A composition for use in an aqueous environment which comprise a formulation containing a water-soluble pharmaceutically beneficial agent, a water-insoluble, water-permeable film coating surrounding the formulation, and particulate, water-soluble, pore-forming material dispersed within the film coating.

Claims

1. A tablet comprising a core containing the admixture of a water-soluble medicine and a water-soluble osmotic enhancing agent in an amount by weight about equal to or greater than the weight of the medicine, said core having a water-insoluble, water-permeable coating surrounding said core, said coating containing particulate, water-soluble, pore-forming material dispersed therein.

2. The tablet of claim 1 in which the osmotic enhancing agent is a pharmaceutically acceptable water-soluble sugar or salt.

3. The tablet of claim 2 in which the pore forming material dispersed in the coating is a pharmaceutically acceptable water-soluble sugar or salt.

4. The tablet of claim 1 in which the osmotic enhancing agent and the pore-forming material are both lactose.

5. A composition comprising a core containing the admixture of a water-soluble medicine and a water-soluble osmotic enhancing agent in an amount by weight about equal to or greater than the weight of the medicine, said core having a water-insoluble, water-permeable coating surrounding said core, said coating containing particulate, water-soluble, pore-forming material dispersed therein and an agent to increase the water permeability of the coating dispersed therein.

6. The composition of claim 5 wherein the water permability increasing agent is polyethylene glycol.