Peptide hydroxamic acid derivatives

• US 4,687,841 A
• Filed: 10/18/1985
• Issued: 08/18/1987
• Est. Priority Date: 10/18/1985
• Status: Expired due to Term

• Current Assignee: Monsanto Company St Louis Missouri
• Original Assignee: Monsanto Company (Bayer AG)
• Inventors: Moore, William McC., Spilburg, Curtis A.
• Primary Examiner(s): Foelak, Morton
• Assistant Examiner(s): Nutter, Nathan M.
• Application Number:
  US06/789,271
• Time in Patent Office: 669 Days
• Field of Search: 530/331, 530/810, 530/813
• US Class Current: 530/331
• CPC Class Codes: C07K 5/0823 and Pro-amino acid; Derivatives thereof
• CPC Class Codes: Y02P 20/55 Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
• CPC Class Codes: Y10S 530/81 Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
• CPC Class Codes: Y10S 530/813 Carrier is a saccharide

Abstract

Novel peptide hydroxamic acid derivatives having useful collagenase inhibitory activity and capable of forming affinity resins for the purification of vertebrate collagenase are defined by the following structural formula:

R-Pro-Leu-Gly-NHOH

wherein R=H or N-protecting group or agarose.

Claims

1. A peptide hydroxamic acid derivative having the following structural formula:

space="preserve" listing-type="equation">R-Pro-Leu-Gly-NHOH

wherein R=H or N-protecting group or agarose.

2. The peptide hydroxamic acid derivative of claim 1 in which R is an N-protecting group.

3. The peptide hydroxamic acid derivative of claim 1 in which R is agarose.