Electromagnetic therapy control system

• US 4,690,130 A
• Filed: 12/19/1985
• Issued: 09/01/1987
• Est. Priority Date: 12/19/1985
• Status: Expired due to Fees

• Current Assignee: Magnacon Incorporated
• Original Assignee: Magnacon Incorporated
• Inventors: Mirell, Stuart G.
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): HINDENBURG, MAX F
• Application Number:
  US06/811,159
• Time in Patent Office: 621 Days
• Field of Search: 128/1.1-1.3, 128/1 R, 128/654, 252/62.53, 252/62.54, 424/1.1, 424/85
• US Class Current: 600/2
• CPC Class Codes: A61F 2007/009 with a varying magnetic field acting upon the human body, e.g. an implant therein
• CPC Class Codes: A61K 41/0052 Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
• CPC Class Codes: A61K 9/5094 Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
• CPC Class Codes: A61N 1/40 Applying electric fields by inductive or capacitive coupling microwave apparatus A61N5/00; Applying radio-frequency signals
• CPC Class Codes: A61N 1/406 using implantable thermoseeds or injected particles for localized hyperthermia preparations of seeds and particles A61K41/0052

Abstract

Chemotherapy may be selectively localized to a tumor located at a point well within the human body by physically associating the chemotherapy agent with magnetic material having a Curie point temperature slightly above the normal temperature of the human body. Both materials may be associated with protein microspheres such as human serum albumin. By applying a magnetic field to the tumor location and then applying electromagnetic radiation to heat the Curie point magnetic material (so that it loses its magnetic properties), away from the tumor site, but not at the tumor site, the unheated magnetic material and the physically associated chemotherapy agent will be localized at the tumor. Radioactive material may also be employed to facilitate imaging of the concentration of the microspheres and for radiation treatment.

Claims

1. A method for applying a therapeutic agent to a treatment zone in a patient, which treatment zone is not adjacent the skin of the patient, comprising:

applying a steady or low frequency magnetic field to the patient to include the treatment zone;

supplying microspheres for circulation through the patient to include said zone, said microspheres including a therapeutic agent, and also includes medically bodily compatible magnetic material having a Curie point at which the magnetic material becomes substantially non-magnetic slightly above the normal body temperature of the patient; and

applying high frequency electromagnetic field energy to said patient where said magnetic field is applied to said patient, except to said treatment zone, to heat up said magnetic material to demagnetize it so the microspheres are not restrained by said magnetic field except in said treatment zone.

2. A method as defined in claim 1 including the step of adding a radiation emitting material to said microspheres and determining the concentration of said microspheres at different locations within said patient from the output radiation.

3. A method as defined in claim 2 including the additional step of modifying the application of the magnetic field and the high frequency electromagnetic field to increase the concentration of microspheres in the treatment area in accordance with the concentration determination.

4. A method as defined in claim 1 wherein the application of a high frequency field includes the step of directing high frequency electromagnetic field energy having the same frequency from two different radiating sources, and means for adjusting the relative phase of the radiation for destructive interference or substantial cancellation at the treatment zone.

5. A method as defined in claim 1 wherein the magnetic field is applied to the patient from a predetermined direction adjacent the skin of the patient and wherein said high frequency electromagnetic energy is applied to the patient from substantially the same direction, at an intensity level sufficient to heat the magnetic material toward the adjacent surface of the body but not to heat the magnetic material in the treatment area beyond the Curie point temperature.

6. A method as defined in claim 1 wherein the applying of a high frequency electromagnetic field provides a sharper delineation of microsphere concentration at the boundaries of the treatment zone by the cancellation of magnetic field components adjacent to said treatment zone n conjunction with the magnetic materials having an electrically conductive composition.

7. A system as defined in claim 6 wherein said objects including Curie point material are microspheres which also contain a therapeutic agent.

8. A system for applying a therapeutic agent to a treatment zone in a patient, which treatment zone is not adjacent the skin of the patient, comprising:

means for applying a steady or low frequency magnetic field to the patient to include the treatment zone;

means for supplying microspheres for circulation through the patient to include said zone, said microspheres including a therapeutic agent, and also includes medically, bodily compatible magnetic material having a Curie point at which the magnetic material becomes substantially non-magnetic slightly above the normal body temperature of the patient; and

means for applying high frequency electromagnetic field energy to said patient where said magnetic field is applied to said patient, except to said treatment zone, to heat up said magnetic material to demagnetize it so the microspheres are not restrained by said magnetic field except in said treatment zone.

9. A system as defined in claim 8 wherein radiation emitting material is included in said microspheres.

10. A system as defined in claim 9 including means sensitive to said radiation for determining the location of said microspheres.

11. A system as defined in claim 8 wherein means for emitting gamma rays and means for emitting beta rays are included in said microspheres.

12. A system as defined in claim 8 wherein the means for applying a high frequency field includes means for directing high frequency electromagnetic field energy having the same frequency from two different radiating sources, and means for adjusting the relative phase of the radiation for destructive interference or substantial cancellation at the treatment zone.

13. A system as defined in claim 8 wherein the magnetic field is applied to the patient from a predetermined direction adjacent the skin of the patient and wherein said high frequency electromagnetic energy is applied to the patient from substantially the same direction, at an intensity level sufficient to heat the magnetic material toward the adjacent surface of the body but at an intensity insufficient to heat the magnetic material in the treatment area beyond the Curie point temperature.