Non-invasive electromagnetic technique for monitoring physiological changes in the brain

• US 4,690,149 A
• Filed: 10/28/1985
• Issued: 09/01/1987
• Est. Priority Date: 10/28/1985
• Status: Expired due to Term

• Current Assignee: Johns Hopkins University
• Original Assignee: Johns Hopkins University
• Inventors: Ko, Harvey W.
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): Smith, Ruth S.
• Application Number:
  US06/791,864
• Time in Patent Office: 673 Days
• Field of Search: 128/1.3-1.5, 128/653, 128/734, 128/748, 128/630
• US Class Current: 600/409
• CPC Class Codes: A61B 5/0507 using microwaves or terahertz waves
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/4064 Evaluating the brain A61B5/031, A61B5/369, A61B5/14553 take precedence

Abstract

An apparatus and method for non-invasively sensing physiological changes in the brain is disclosed. The apparatus and method uses an electromagnetic field to measure localized impedance changes in brain matter and fluid. Various spatial and temporal techniques are used to localize impedance changes in the brain. The apparatus and method has particular application in locating and providing time-trend measurements of the process of brain edema or the process of hydrocephalus.

Claims

1. A method for locating edematous tissue within the white or grey matter of an animal or human brain, comprising:

noninvasively detecting the impedance due to brain tissue and other biological matter at a plurality of localized portions within the brain, wherein said detecting step for each of said plurality of localized portions comprises the steps of;

a. producing an oscillating magnetic field that is spatially concentrated in a localized portion of a brain using a coil means, whereby eddy currents induce a secondary magnetic emission which alters the mutual inductance of said coil means in accordance with the impedance of brain tissue and other biological matter in said portion, and

b. measuring a change in the mutual inductance of said coil means, wherein an increase in mutual inductance indicates an increase in impedance and a decrease in mutual inductance indicates a decrease in impedance; and

,

comparing the impedance detected at each portion of the brain to determine the location of higher impedance regions within the white or grey matter of the brain that indicate the location of edematous tissue.

2. The method of claim 1 wherein said producing step involves the step of generating a spatially concentrated magnetic field in a horizontal section of the brain using a loop coil adapted to encompass a patient'"'"'s cranium.

3. The method of claim 1 wherein said producing step involves the step of generating a concentrated magnetic field for each portion using a solenoid coil positioned proximal to the surface of a patient'"'"'s cranium.

4. The method of claim 1, wherein said producing step involves the step of varying the spatial concentration of said magnetic field by varying the frequency of said magnetic field.

5. The method of claim 1, wherein said producing step involves the step of varying the spatial concentration of said magnetic field by varying the waveform of said magnetic field.

6. The method of claim 4 or 5, wherein said measuring step involves detecting changes in mutual inductance as the spatial concentration of said magnetic field is varied.

7. The method of claim 1, further comprising the step of:

mapping impedance contours of at least a section of the brain to located edematous tissue using the magnitude of mutual inductance detected for a particular localized portion of the brain, wherein localized portions having a higher concentration of edematous tissue will produce a higher mutual inductance.