Method for delivering an active ingredient by controlled time release utilizing a novel delivery vehicle which can be prepared by a process utilizing the active ingredient as a porogen
First Claim
1. A composition of matter useful as a time-release delivery vehicle for delivering an active ingredient by controlled time release, comprising a porous polymeric bead having a network of pores with the active ingredient held within the network of pores, said network of pores being substantially non-collapsible upon removal of the active ingredient.
2 Assignments
0 Petitions
Accused Products
Abstract
Delivery vehicles comprised of a polymeric bead having a network of pores with an active ingredient held within the network are provided for use in a method to provide controlled release of the active ingredient. The network of pores is substantially non-collapsible upon removal of the active ingredient and the delivery vehicles are polymerized by a process in which the active ingredient also comprises the porogen during formation of the network of pores.
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Citations
80 Claims
- 1. A composition of matter useful as a time-release delivery vehicle for delivering an active ingredient by controlled time release, comprising a porous polymeric bead having a network of pores with the active ingredient held within the network of pores, said network of pores being substantially non-collapsible upon removal of the active ingredient.
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8. A process for preparing a time-release delivery vehicle useful for delivering an active ingredient by controlled release, comprising the steps of:
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dissolving at least one monomer in an inert porogen to form a solution; suspending the solution in a phase incompatible with the solution; agitating the solution and the phase to form a plurality of droplets of the solution suspended in the phase; activating at least one monomer in the plurality of droplets to polymerize at least one monomer and form a porous bead having a network of pores with the porogen held within the network of pores, said network of pores being substantially non-collapsible upon removal of the porogen; separating the porous polymeric bead from the phase; removing any impurity from the porous polymeric bead; and retaining the porogen within the network of pores as the active ingredient to form the delivery vehicle. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15)
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16. A method for delivering an active ingredient by controlled time release, comprising the steps of:
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mixing a delivery vehicle with a medium to form a mixture, said delivery vehicle comprising a porous polymeric bead having a network of pores with the active ingredient held within the network of pores said network of pores being substantially non-collapsible upon removal of the active ingredient; applying the mixture to a surface; and releasing the active ingredient from the network of pores. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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- 28. A composition of matter useful as a time-release delivery vehicle for delivering an active ingredient by controlled time release, comprising a porous polymeric bead of styrene divinylbenzene having a network of pores with the active ingredient held within the network of pores, said network of pores being substantially non-collapsible upon removal of the active ingredient.
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34. A process for preparing a time-release delivery vehicle useful for delivering an active ingredient by controlled time-release, comprising the steps of:
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dissolving styrene and divinylbenzene in an inert porogen to form a solution; suspending the solution in a phase incompatible with the solution; agitating a plurality of the solution and the phase to form droplets of the solution suspended in the phase; activating styrene and divinylbenzene in the plurality of droplets to copolymerize the styrene and divinylbenzene and form at least one porous polymeric bead of styrene divinylbenzene having a network of pores with the porogen held within the network of pores, said network of pores being substantially non-collapsible upon removal of the porogen; separating the porous polymeric bead from the phase; removing any impurity from the porous polymeric bead; and retaining the porogen within the network of pores as the active ingredient to form the time-release delivery vehicle. - View Dependent Claims (35, 36, 37, 38, 39)
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40. A method for delivering an active ingredient by controlled time release;
- comprising the steps of;
mixing a delivery vehicle with a medium to form a mixture, said delivery vehicle comprising a porous polymeric bead of styrene divinylbenzene having a network of pores with the active ingredient held within the network of pores, said network of pores being substantially non-collapsible upon removal of the active ingredient; applying the mixture to a surface; and releasing the active ingredient from the network of pores. - View Dependent Claims (41, 42, 43, 44, 45, 46, 47, 48, 49, 50)
- comprising the steps of;
- 51. A composition of matter useful as a time-release delivery vehicle for delivering an active ingredient by controlled time release, comprising a porous polymeric bead having a network of pores with the active ingredient held within the network of pores, said composition having a calculated cross-linking density and an active ingredient concentration such that substantially all of the active ingredient will be released from the network of pores when the bead is placed in a solvent in which the active ingredient is soluble for a sufficient length of time to wet the bead.
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60. A process for preparing a time-release delivery vehicle useful for delivering an active ingredient by controlled time-release, comprising the steps of:
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dissolving at least one monomer in an inert porogen to form a solution; suspending the solution in a phase incompatible with the solution; agitating the solution and the phase to form a plurality of droplets of the solution suspended in the phase; activating at least one monomer in the plurality of droplets to polymerize at least one monomer and form a porous bead having a network of pores with the porogen held within the network of pores; separating the porous polymeric bead from the phase; removing any impurity from the porous polymeric bead; and retaining the porogen within the network of pores as the active ingredient to form the delivery vehicle, said delivery vehicle having a calculated cross-linking density and an active ingredient concentration such that substantially all of the active ingredient will be released from the network of pores when the bead is placed in a solvent in which the active ingredient is soluble for a sufficient length of time to wet the bead. - View Dependent Claims (61, 62, 63, 64, 65, 66, 67)
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68. A method for delivering an active ingredient by controlled time release, comprising the steps of:
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mixing a delivery vehicle with a medium to form a mixture, said delivery vehicle comprising a porous polymeric bead having a network of pores with the active ingredient held within the network of pores, said delivery vehicle having a calculated cross-linking density and an active ingredient concentration such that substantially all of the active ingredient will be released from the network of pores when the bead is placed in a solvent of pores in which the active ingredient is soluble for a sufficient length of time to wet the bead; applying the mixture to a surface; and
releasing the active ingredient from the network of pores. - View Dependent Claims (69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80)
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Specification