Dispenser comprising inner positioned soft or hard capsule

• US 4,692,326 A
• Filed: 02/14/1986
• Issued: 09/08/1987
• Est. Priority Date: 03/21/1984
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Eckenhoff, James B., Theeuwes, Felix, Deters, Joseph C.
• Primary Examiner(s): Rose, Shep K.
• Application Number:
  US06/829,353
• Time in Patent Office: 571 Days
• Field of Search: 604/890, 424/15, 424/19, 424/20, 424/21, 424/22, 424/37, 424/38
• US Class Current: 424/473
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

A dispenser is disclosed for delivering a beneficial agent to an environment of use. The dispenser comprises a semipermeble wall surrounding a compartment containing a heat responsive composition, and an expandable composition. A passageway in the wall connects the compartment with the exterior of the dispenser.

Claims

1. A dispenser for dispensing a beneficial drug to a biological environment of use, wherein the dispenser comprises:

(a) a wall comprising in at least a part a semipermeable composition permeble to the passage of fluid and substantially impermeable to the passage of the beneficial drug which wall surrounds;

(b) a capsule, which capsule is a member selected from the group consisting of a hard capsule and a soft capsule;

(c) means in the capsule for forming a dispensable composition in response to the temperature of the biological environment of use, which thermo-responsive means is a member selected from the group consisting of a wax, butter, stearate, partially hydrogenated oil, hydrogenated oil, ester, ether, polyoxyalkylene, glyceride of fatty acid, fatty acid, and copolymer of alkylene oxide;

(d) a dosage amount of a beneficial drug present in the thermo responsive means for forming the dispensable composition;

(e) means in the capsule for increasing in volume and for occupying an increasing amount of the capsule for urging the dispensable composition from the dispenser, said means a solid osmotically effective polymeric composition that interacts with fluid and expands; and

,

(f) at least one orifice in the dispenser for delivering the dispensable composition comprising the beneficial drug from the dispenser.