Compositions and method of controlling transdermal penetration of topical and systemic agents
First Claim
1. A pharmaceutical composition for the controlled transdermal delivery of one or more pharmacologically active systemic drugs comprising a safe and effective amount of a systemic drug-ion exchange resin complex and a salt effective to control the drug release note, containing the appropriate counter ion for the ion-exchange resin, selected from the group consisting of sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, zinc sulfate, magnesium chloride, calcium chloride, potassium chloride, sodium sulfate, sodium acetate, magnesium acetate and sodium citrate in a gel-forming vehicle.
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Abstract
Compositions and methods useful for improved and controlled transdermal and transmembrane drug delivery of topical and systemic agents. The compositions and methods comprise a pharmacologically active drug together with a non-toxic pharmaceutically acceptable ion exchange resin, and a salt in a gel-forming vehicle and topically administering to human or animal skin or other membranes the resulting compositions. If desired, a penetration enhancer may also be employed in the compositions of this invention.
74 Citations
11 Claims
- 1. A pharmaceutical composition for the controlled transdermal delivery of one or more pharmacologically active systemic drugs comprising a safe and effective amount of a systemic drug-ion exchange resin complex and a salt effective to control the drug release note, containing the appropriate counter ion for the ion-exchange resin, selected from the group consisting of sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, zinc sulfate, magnesium chloride, calcium chloride, potassium chloride, sodium sulfate, sodium acetate, magnesium acetate and sodium citrate in a gel-forming vehicle.
- 7. A method for controlling the transdermal penetration of one or more non-toxic pharmacologically active systemic drugs to a patient which comprises applying to said patient a composition comprising a systemic drug-ion exchange resin complex and a salt effective to control the drug release note, containing the appropriate counter ion for the ion-exchange resin, selected from the group consisting of sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, zinc sulfate, magnesium chloride, calcium chloride, potassium chloride, sodium sulfate, sodium acetate, magnesium acetate and sodium citrate in a gel-forming vehicle.
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9. In a device for use in the controlled transdermal delivery of pharmacologically active systemic drugs provided with a cavity having an inert backing member which is impermeable to said systemic drugs, the improvement comprising said cavity containing a composition comprising a systemic drug-ion exchange resin complex and a salt effective to control the drug release note, containing the appropriate counter ion for the ion-exchange resin, selected from the group consisting of sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, zinc sulfate, magnesium chloride, calcium chloride, potassium chloride, sodium sulfate, sodium acetate, magnesium acetate and sodium citrate in a gel-forming vehicle.
- 10. A device for use in the controlled transdermal administration of pharmacologically active systemic drugs comprising a cavity, a backing member impermeable to said systemic drugs surrounding said cavity, an adhesive layer on said backing member, said cavity containing a composition comprising a systemic drug ion exchange resin complex and a salt effective to control the drug release note, containing the appropriate counter ion for the ion-exchange resin, selected from the group consisting of sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, zinc sulfate, magnesium chloride, calcium chloride, potassium chloride, sodium sulfate, sodium acetate, magnesium acetate and sodium citrate in a gel forming vehicle which provides a controlled rate of systemic drug release.
Specification