Method for alleviating skin irritation by formulations containing superoxide dismutase
First Claim
1. A method for the alleviation of dermal chemical irritation, dermal chemical inflammation or acne of the skin of a human, comprising applying at an area concentration of at least about 0.002 ml or 2 mg per square cm, a topical formulation containing a non-toxic, non-allergenic carrier and at least about 0.026 weight percent relative to the total weight of the formulation, of purified superoxide dismutase having an activity of at least about 3800 C.I.U./mg or an extract having an equivalent activity thereof, to the skin of said human having chemical irritation, inflammation or acne of the skin.
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Abstract
This invention discloses use of superoxide dismutase (SOD) as an agent for the protection of the skin against inflammatory reactions associated with chemical irritation and acne. Topical application of SOD in a formulation attenuates dermal injury associated with the induction of reactive oxygen species by a wide variety of chemical irritants, associated with inflammation, and associated with acne.
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Citations
24 Claims
- 1. A method for the alleviation of dermal chemical irritation, dermal chemical inflammation or acne of the skin of a human, comprising applying at an area concentration of at least about 0.002 ml or 2 mg per square cm, a topical formulation containing a non-toxic, non-allergenic carrier and at least about 0.026 weight percent relative to the total weight of the formulation, of purified superoxide dismutase having an activity of at least about 3800 C.I.U./mg or an extract having an equivalent activity thereof, to the skin of said human having chemical irritation, inflammation or acne of the skin.
- 9. A method for the alleviation of dermal chemical irritation, dermal chemical inflammation or acne of the skin of a human, comprising applying at an area concentration of at least about 0.002 ml or 2 mg per square cm, a topical formulation containing a non-toxic, non-allergenic carrier and an amount of superoxide dismutase (SOD) sufficient to deliver at least abvout 1 CIU of SOD per square cm.
- 14. A method for the alleviation of dermal chemical irritation, dermal chemical inflammation or acne of the skin of an animal, comprising applying at an area concentration of at least about 0.002 ml or 2 mg per square cm, a topical formulation containing a non-toxic, non-allergenic carrier and at least about 0.026 weight percent relative to the total weight of the fomulation, of purified superoxide dismutase having an activity of at least about 3800 C.I.U./mg or an extract having an equivalent activity thereof, to the skin of said animal having chemical irritation, inflammation or acne of the skin.
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22. A method for the alleviation of dermal chemical irritation, dermal chemical inflammation or acne of the skin of an animal, comprising applying at an area concentration of at least about 0.002 ml or 2 mg per square cm, a topical formulation containing a non-toxic, non-allergenic carrier and an amount of superoxide dismutase (SOD) sufficient to deliver at least about 1
CIU of SOD per square cm.
Specification