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Coated transplants and method for making same

  • US 4,696,286 A
  • Filed: 05/22/1986
  • Issued: 09/29/1987
  • Est. Priority Date: 03/14/1985
  • Status: Expired due to Term
First Claim
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1. A transplant suitable for transplantation into a genetically dissimilar individual, said transplant being coated with an immunological barrier membrane that conforms to the surface of the transplant,said membrane comprising a noncytotoxic inner layer that is bonded chemically to the surface of the transplant, and an outer, biologically compatible, water-insoluble semipermeable layer bonded chemically to the inner layer, wherein the inner layer is comprised of a material selected from the group consisting of:

  • (a) aluminum hydroxide;

    (b) a disaccharide;

    (c) a polyfunctional cross-linking agent;

    (d) an immunoglobulin to a surface component of the transplant;

    (e) a lectin; and

    (f) a polyionic polyamino acid having an opposite charge to that of the transplant surface; and

    the outer layer is comprised of a polyamino acid that has reactive carboxyl, amino or imino side groups.

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