Coated transplants and method for making same
First Claim
1. A transplant suitable for transplantation into a genetically dissimilar individual, said transplant being coated with an immunological barrier membrane that conforms to the surface of the transplant,said membrane comprising a noncytotoxic inner layer that is bonded chemically to the surface of the transplant, and an outer, biologically compatible, water-insoluble semipermeable layer bonded chemically to the inner layer, wherein the inner layer is comprised of a material selected from the group consisting of:
- (a) aluminum hydroxide;
(b) a disaccharide;
(c) a polyfunctional cross-linking agent;
(d) an immunoglobulin to a surface component of the transplant;
(e) a lectin; and
(f) a polyionic polyamino acid having an opposite charge to that of the transplant surface; and
the outer layer is comprised of a polyamino acid that has reactive carboxyl, amino or imino side groups.
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Accused Products
Abstract
Transplants, such as pancreatic islets, are made suitable for transplantation into a genetically dissimilar individual by coating the transplant with a surface-conforming bonding bridge layer of a multifunctional material that binds chemically to a surface component of the transplant followed by a semipermeable, biologically compatible layer of a polymer that binds chemically to the bonding bridge layer.
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Citations
16 Claims
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1. A transplant suitable for transplantation into a genetically dissimilar individual, said transplant being coated with an immunological barrier membrane that conforms to the surface of the transplant,
said membrane comprising a noncytotoxic inner layer that is bonded chemically to the surface of the transplant, and an outer, biologically compatible, water-insoluble semipermeable layer bonded chemically to the inner layer, wherein the inner layer is comprised of a material selected from the group consisting of: -
(a) aluminum hydroxide; (b) a disaccharide; (c) a polyfunctional cross-linking agent; (d) an immunoglobulin to a surface component of the transplant; (e) a lectin; and (f) a polyionic polyamino acid having an opposite charge to that of the transplant surface; and
the outer layer is comprised of a polyamino acid that has reactive carboxyl, amino or imino side groups. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method of treating a transplant to make it suitable for transplantation into a genetically dissimilar individual comprising:
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coating the transplant with a first or inner layer of a noncytotoxic material that forms a chemical bond with the surface of the transplant, said first layer conforming to the surface of the transplant, said first layer comprised of a material selected from the group consisting of (a) aluminum hyhdroxide; (b) a disaccharide; (c) a polyfunctional cross-linking agent; (d) an immunoglobulin to a surface component of the transplant; (e) a lectin; and (f) a polyionic polyamino acid having an opposite charge to that of the transplant surface; and coating the transplant with a second or outer layer of a polymeric material that forms a chemical bond with the material of the first layer, said second layer being biologically compatible and semipermeable, said second layer comprising a polyamino acid that has reactive carboxyl, amino or imino side groups. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
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Specification